![](/images/graphics-bg.png)
Bladder Cancer and Urothelial Impairment : The Role of TRPV1 as Potential Drug Target
المؤلفون المشاركون
Abrate, Alberto
Larcher, Alessandro
Buffi, Nicolò Maria
Fossati, Nicola
Lista, Giuliana
Lazzeri, Massimo
Montorsi, Francesco
Dell’Oglio, Paolo
Lughezzani, Giovanni
Mistretta, Francesco
Guazzoni, Giorgio
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-08
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Urothelium, in addition to its primary function of barrier, is now understood to act as a complex system of cell communication that exhibits specialized sensory properties in the regulation of physiological or pathological stimuli.
Furthermore, it has been hypothesized that bladder inflammation and neoplastic cell growth, the two most representative pathological conditions of the lower urinary tract, may arise from a primary defective urothelial lining.
Transient receptor potential vanilloid channel 1 (TRPV1), a receptor widely distributed in lower urinary tract structures and involved in the physiological micturition reflex, was described to have a pathophysiological role in inflammatory conditions and in the genesis and development of urothelial cancer.
In our opinion new compounds, such as curcumin, the major component of turmeric Curcuma longa, reported to potentiate the effects of the chemotherapeutic agents used in the management of recurrent urothelial cancer in vitro and also identified as one of several compounds to own the vanillyl structure required to work like a TRPV1 agonist, could be thought as complementary in the clinical management of both the recurrences and the inflammatory effects caused by the endoscopic resection or intravesical chemotherapy administration or could be combined with adjuvant agents to potentiate their antitumoral effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mistretta, Francesco& Buffi, Nicolò Maria& Lughezzani, Giovanni& Lista, Giuliana& Larcher, Alessandro& Fossati, Nicola…[et al.]. 2014. Bladder Cancer and Urothelial Impairment : The Role of TRPV1 as Potential Drug Target. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-513872
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mistretta, Francesco…[et al.]. Bladder Cancer and Urothelial Impairment : The Role of TRPV1 as Potential Drug Target. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-513872
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mistretta, Francesco& Buffi, Nicolò Maria& Lughezzani, Giovanni& Lista, Giuliana& Larcher, Alessandro& Fossati, Nicola…[et al.]. Bladder Cancer and Urothelial Impairment : The Role of TRPV1 as Potential Drug Target. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-513872
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513872
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)