Evaluation of CTLA-4 gene polymorphism SNP 49 G A association with diabetes mellitus type 1 in Egyptian population

الملخص EN

The (CTLA-4) encodes of the T cell receptor involved in the control of T cell proliferation and mediates T cell apoptosis.

The contribution of CTLA-4 gene variants to type 1 diabetes has been analyzed in several ethnic groups.

In this study, the association of CTLA-4 + 49 A / G polymorphism with type 1 diabetes was investigated in Egyptian patients.

Sixty type 1 diabetic patients (25 males and 35 females) and 60 healthy individuals (33 males and 27 females) subjects formed the studied populations.

CTLA-4 A / G polymorphism at position 49 in exon 1 was identified using allele specific methods.

Patient numbers with A / G, A / A and G / G genotypes were 45 (75.0 %), 6 (10.0 %) and 9 (15.0 %) while in healthy controls, these were 48 (80.0 %), 2 (3.3 %) and 10 (16.7 %), respectively.

In conclusion, the results of this study showed that CTLA-4 + 49 A / G polymorphism were not associated with susceptibility to type 1 diabetes in Egyptian population.