Association of β-fibrinogen promoter gene polymorphism (-148c t), hyperfibrinogenemia and ischemic stroke in young adult patients
المؤلفون المشاركون
Harapan, Harapan
Umran, Umran
Lamsudin, Rusdi
Idjradinata, Ponpon
Achmad, Tri Hanggono
Maskoen, Amelani
Wibowo, Samekto
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 16، العدد 1 (31 مارس/آذار 2015)، ص ص. 11-17، 7ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2015-03-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Single nucleotide polymorphism (SNP)-148C / T which is located in bfibrinogen gene (FGB) promoter has correlation with fibrinogen levels ; however, the association of SNP-148C / T and ischemic stroke in young adult patients is contradictory.
Aim : To determine the association of SNP-148C / T in FGB promoter with plasma fibrinogen levels and ischemic stroke in young adults.
Subjects and methods : In this case-control study, SNP-148C / T among 107 ischemic stroke patients and 94 controls were evaluated by PCR-RFLP with restriction enzyme HindIII and confirmed by DNA sequencing.
Physical and neurological examinations, brain computed tomography, plasma fibrinogen levels and blood biochemistry tests were assessed within seven days after the onset of symptoms.
Genotype distributions and allele frequencies were analyzed by chi-squared test.
Results : This study found that the level of fibrinogen was significantly higher in ischemic stroke group than control (419.2 mg / dL vs.
351.1 mg / dL, p 6 0.000) and the level of fibrinogen associated with ischemic stroke (OR, 2.28 ; 95 % CI, 1.28-4.07, p = 0.005).
Mutant genotypes (CT and TT) and T allele had a significant association with hyperfibrinogenemia (OR, 2.58 ; 95 % CI, 1.39-4.76 and OR, 1.6 ; 95 % CI, 1.60-2.41, respectively) and ischemic stroke (OR, 2.46 ; 95 % CI, 1.37-4.41 and OR, 1.80 ; 95 % CI 1.19-2.73, respectively).
In addition, analysis adjusted for other risk factors found that mutant genotypes correlated with hyperfibrinogenemia and ischemic stroke (OR, 2.27 ; 95 % CI, 1.21-4.25 and OR, 2.16 ; 95 % CI, 1.19-3.94, respectively).
Conclusion : There was a significant association between SNP-148C / T and fibrinogen levels, SNP-148C / T and ischemic stroke, and fibrinogen levels and ischemic stroke.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Umran, Umran& Lamsudin, Rusdi& Idjradinata, Ponpon& Achmad, Tri Hanggono& Maskoen, Amelani& Wibowo, Samekto…[et al.]. 2015. Association of β-fibrinogen promoter gene polymorphism (-148c t), hyperfibrinogenemia and ischemic stroke in young adult patients. The Egyptian Journal of Medical Human Genetics،Vol. 16, no. 1, pp.11-17.
https://search.emarefa.net/detail/BIM-517559
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Umran, Umran…[et al.]. Association of β-fibrinogen promoter gene polymorphism (-148c t), hyperfibrinogenemia and ischemic stroke in young adult patients. The Egyptian Journal of Medical Human Genetics Vol. 16, no. 1 (2015), pp.11-17.
https://search.emarefa.net/detail/BIM-517559
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Umran, Umran& Lamsudin, Rusdi& Idjradinata, Ponpon& Achmad, Tri Hanggono& Maskoen, Amelani& Wibowo, Samekto…[et al.]. Association of β-fibrinogen promoter gene polymorphism (-148c t), hyperfibrinogenemia and ischemic stroke in young adult patients. The Egyptian Journal of Medical Human Genetics. 2015. Vol. 16, no. 1, pp.11-17.
https://search.emarefa.net/detail/BIM-517559
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 16-17
رقم السجل
BIM-517559
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر