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Association of β-fibrinogen promoter gene polymorphism (-148c t), hyperfibrinogenemia and ischemic stroke in young adult patients
Joint Authors
Harapan, Harapan
Umran, Umran
Lamsudin, Rusdi
Idjradinata, Ponpon
Achmad, Tri Hanggono
Maskoen, Amelani
Wibowo, Samekto
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 16, Issue 1 (31 Mar. 2015), pp.11-17, 7 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2015-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background : Single nucleotide polymorphism (SNP)-148C / T which is located in bfibrinogen gene (FGB) promoter has correlation with fibrinogen levels ; however, the association of SNP-148C / T and ischemic stroke in young adult patients is contradictory.
Aim : To determine the association of SNP-148C / T in FGB promoter with plasma fibrinogen levels and ischemic stroke in young adults.
Subjects and methods : In this case-control study, SNP-148C / T among 107 ischemic stroke patients and 94 controls were evaluated by PCR-RFLP with restriction enzyme HindIII and confirmed by DNA sequencing.
Physical and neurological examinations, brain computed tomography, plasma fibrinogen levels and blood biochemistry tests were assessed within seven days after the onset of symptoms.
Genotype distributions and allele frequencies were analyzed by chi-squared test.
Results : This study found that the level of fibrinogen was significantly higher in ischemic stroke group than control (419.2 mg / dL vs.
351.1 mg / dL, p 6 0.000) and the level of fibrinogen associated with ischemic stroke (OR, 2.28 ; 95 % CI, 1.28-4.07, p = 0.005).
Mutant genotypes (CT and TT) and T allele had a significant association with hyperfibrinogenemia (OR, 2.58 ; 95 % CI, 1.39-4.76 and OR, 1.6 ; 95 % CI, 1.60-2.41, respectively) and ischemic stroke (OR, 2.46 ; 95 % CI, 1.37-4.41 and OR, 1.80 ; 95 % CI 1.19-2.73, respectively).
In addition, analysis adjusted for other risk factors found that mutant genotypes correlated with hyperfibrinogenemia and ischemic stroke (OR, 2.27 ; 95 % CI, 1.21-4.25 and OR, 2.16 ; 95 % CI, 1.19-3.94, respectively).
Conclusion : There was a significant association between SNP-148C / T and fibrinogen levels, SNP-148C / T and ischemic stroke, and fibrinogen levels and ischemic stroke.
American Psychological Association (APA)
Umran, Umran& Lamsudin, Rusdi& Idjradinata, Ponpon& Achmad, Tri Hanggono& Maskoen, Amelani& Wibowo, Samekto…[et al.]. 2015. Association of β-fibrinogen promoter gene polymorphism (-148c t), hyperfibrinogenemia and ischemic stroke in young adult patients. The Egyptian Journal of Medical Human Genetics،Vol. 16, no. 1, pp.11-17.
https://search.emarefa.net/detail/BIM-517559
Modern Language Association (MLA)
Umran, Umran…[et al.]. Association of β-fibrinogen promoter gene polymorphism (-148c t), hyperfibrinogenemia and ischemic stroke in young adult patients. The Egyptian Journal of Medical Human Genetics Vol. 16, no. 1 (2015), pp.11-17.
https://search.emarefa.net/detail/BIM-517559
American Medical Association (AMA)
Umran, Umran& Lamsudin, Rusdi& Idjradinata, Ponpon& Achmad, Tri Hanggono& Maskoen, Amelani& Wibowo, Samekto…[et al.]. Association of β-fibrinogen promoter gene polymorphism (-148c t), hyperfibrinogenemia and ischemic stroke in young adult patients. The Egyptian Journal of Medical Human Genetics. 2015. Vol. 16, no. 1, pp.11-17.
https://search.emarefa.net/detail/BIM-517559
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 16-17
Record ID
BIM-517559