Serum vascular endothelial growth factor in collagen diseases : correlation with disease activity
المؤلفون المشاركون
Izz al-Din, Maha
Fayiz, Dalia
Mabruk, Ilham Abd al-Zahir
Khafaji, Naziha Hafiz
Ulwan, Ayman Sabri
Mabruk, Salwa Abd al-Zahir
المصدر
Egyptian Rheumatology and Rehabilitation
العدد
المجلد 29، العدد 5 (30 سبتمبر/أيلول 2002)، ص ص. 721-730، 10ص.
الناشر
الجمعية المصرية للروماتيزم و التأهيل
تاريخ النشر
2002-09-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: A role for angiogenic factors such as vascular endothelial growth factor (VEGF) in the pathogenesis of collagen diseases through endothelial cell modulation has been suggested.
Aim of the work: Assessment of serum VEGF level in rheumatoid arthritis (RA), systemic sclerosis (SSc) and systemic lupus erythematosus (SLE) patients to elucidate the potential involvement of VEGF in the pathogenesis of these diseases.
Also, to find out a relation between its serum level and the disease activity or the functional impairment in those patients.
Study design: The serum level of VEGF was assessed in 10 RA patients; 10 SSc patients; 10 SLE patients as well as 10 healthy volunteers.
Its level was correlated to the different clinical & laboratory parameters of disease activity and functional impairment in the patients.
Results: When compared with the control group, each group of patients showed a significantly higher concentration (p<0.001) of serum VEGF.
A statistically significant correlation was found between this higher concentration and disease activity in RA & SLE patients as well as the development of lung fibrosis in SSc patients.
Conclusion: The results of this study suggest that angiogenesis produced by VEGF may play an important role in the pathogenesis of collagen diseases.
Measurement of serum VEGF reflects the disease activity in RA & SLE patients as well as increased frequency of lung fibrosis in SSc patients.
In addition, inhibition of VEGF either by drugs or receptor antagonism may improve the clinical manifestations or decrease the progress of these diseases.
However, further studies are needed to elucidate the exact role of VEGF in relation to other cytokines involved in the pathogenesis of collagen diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mabruk, Ilham Abd al-Zahir& Khafaji, Naziha Hafiz& Ulwan, Ayman Sabri& Mabruk, Salwa Abd al-Zahir& Fayiz, Dalia& Izz al-Din, Maha. 2002. Serum vascular endothelial growth factor in collagen diseases : correlation with disease activity. Egyptian Rheumatology and Rehabilitation،Vol. 29, no. 5, pp.721-730.
https://search.emarefa.net/detail/BIM-52295
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mabruk, Ilham Abd al-Zahir…[et al.]. Serum vascular endothelial growth factor in collagen diseases : correlation with disease activity. Egyptian Rheumatology and Rehabilitation Vol. 29, no. 5 (Sep. 2002), pp.721-730.
https://search.emarefa.net/detail/BIM-52295
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mabruk, Ilham Abd al-Zahir& Khafaji, Naziha Hafiz& Ulwan, Ayman Sabri& Mabruk, Salwa Abd al-Zahir& Fayiz, Dalia& Izz al-Din, Maha. Serum vascular endothelial growth factor in collagen diseases : correlation with disease activity. Egyptian Rheumatology and Rehabilitation. 2002. Vol. 29, no. 5, pp.721-730.
https://search.emarefa.net/detail/BIM-52295
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 729-730
رقم السجل
BIM-52295
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر