Genetic alterations in Iraqi Leukaemia patients as indicator for polluted environment

الملخص EN

Fifty blood samples of leukemia patients were analyzed to detect the genetic alterations associated with disease.

The results showed a high significant DNA damage leukemia group.

A significant (P < 0.05) increase in MN is observed in Acute Lymphoblastic Leukemia (ALL) patients (0.012 ± 0.00056, 0.014 ± 0.00049 MN / cell respectively) and decreased Nuclear Division Index(NDI) level (1.615 ± 0.0052, 1.597 ± 0.0039 respectively ) when compared with control group (0.001 ± 0.00016 ; 1.845 ± 0.0091 respectively).

DNA damage detected in Acute Lymphoblastic Leukemia (ALL) and Chronic Myeloid Leukemia (CML) patients with micronucleus (MN) is confirmed with statistically significantly higher COMET parameters (tail length = 5.11 ± 0.85, 5.66 ± 0.91 ; % DNA mean in tail = 0.072 ± 0.041 %, 0.082 ± 0.039 and tail moment = 0.00044 ± 6.87, 0.00052 ± 5.99 respectively).

The results indicated that the leukemia patients were exposed to a high genotoxicity which damaged the lymphocytes DNA.