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Serological and molecular detection of parvovirus bl9 in children with acute lymphoblastic leukemia
المؤلفون المشاركون
Abd Allah, Shadha F.
al-Jadiri, Mazin F.
Abd Allah, Iqbal M.
المصدر
Journal of the Faculty of Medicine Baghdad
العدد
المجلد 56، العدد 3 (30 سبتمبر/أيلول 2014)، ص ص. 318-321، 4ص.
الناشر
تاريخ النشر
2014-09-30
دولة النشر
العراق
عدد الصفحات
4
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Human parvovirus B19 (B19V) is the only human pathogenic parvovirus, It is highly erythrotropic and preferentially replicates in erythroid progenitor cells (EPCs).
Recently the effects of B19 infection have been well studied in children with acute lymphoblastic leukemia (ALL).
Objective : To detect parvovirus B19 among children with ALL.
Methods : A cross sectional study involved forty five patients with ALL (21 patients were newly diagnosed ALL and 24 children who underwent chemotherapy) who were attending department of oncology in Children's Welfare Teaching Hospital in Baghdad Medical City between December 2012 and April 2013, compared to forty five of apparently healthy children as a control group, age and sex were matched.
A serological and molecular detection of parvovirus B19 were done using enzyme linked immunosorbant assay (ELISA) and Real-time PCR.
Results : B19-IgM, IgG and DNA were detected in study cases as (15.6 %, 40 % and 13.3 %) compared to control group (4.4 %, 13 % and 0 %) respectively.
B19-IgG and B19-IgM were detected in newly diagnosed cases in (41.7 % and 19.05 %) as well as in (38.1 % and 12.
5 %) of cases on chemotherapy respectively, all cases with B19-DNA signals were underwent chemotherapy (25 %) with mean viral load of (36x104 copies / ml).
Conclusion : children who suffering from ALL are at increased risk of B19 infection.
Notable percentage of persistent B19 infection was recorded among children with ALL who are receiving ongoing treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd Allah, Iqbal M.& Abd Allah, Shadha F.& al-Jadiri, Mazin F.. 2014. Serological and molecular detection of parvovirus bl9 in children with acute lymphoblastic leukemia. Journal of the Faculty of Medicine Baghdad،Vol. 56, no. 3, pp.318-321.
https://search.emarefa.net/detail/BIM-526863
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd Allah, Iqbal M.…[et al.]. Serological and molecular detection of parvovirus bl9 in children with acute lymphoblastic leukemia. Journal of the Faculty of Medicine Baghdad Vol. 58, no. 3 (2014), pp.318-321.
https://search.emarefa.net/detail/BIM-526863
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd Allah, Iqbal M.& Abd Allah, Shadha F.& al-Jadiri, Mazin F.. Serological and molecular detection of parvovirus bl9 in children with acute lymphoblastic leukemia. Journal of the Faculty of Medicine Baghdad. 2014. Vol. 56, no. 3, pp.318-321.
https://search.emarefa.net/detail/BIM-526863
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 320-321
رقم السجل
BIM-526863
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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