A study of osteoprotegerin in diabetic patients as indicator for myocardial infarction

الملخص EN

The study included (180) subject (89 males, 91 females), classified into 4 study groups : (49) diabetic patients (21 males, 28females) were attended to the diabetic and endocrinology center at Al-Sader medical city in Al-Najaf Al-Ashraf, and registered in the center as type 2 diabetic mellitus patients (DM) group.

(40) patients (23 males, 17 females) attended to the coronary care unit (CCU) at Al-Sader medical city in Al-Najaf Al-Ashraf and diagnosed as having myocardial infarction (they all showed S-T elevation) (MI) group.

(46) patients (21 males, 25 females) attended to the coronary care unit (CCU) at Al-Sader medical city in Al-Najaf Al-Ashraf and diagnosed as having myocardial infarction (they all showed S-T elevation), and previously diagnosed as type 2 diabetic patients (DMMI) group.

(45) Healthy subjects (24 males, 21 females)vas (control) group.

All patients and control subjects were aged between 40-75 years.

All of them were non obese (Body Mass Index < 30).

Samples collected during the period from May 2011 till February 2012.

The measured parameters include : fasting blood sugar (FBS), glycosylated haemoglobin (HbA1c %), lipid profile (LDL, TG, HDL, vLDL, atherogenic Index), serum Osteoprotegrin (OPG).

The results obtained were : There was a significant increase (P < 0.05) in FBS in DM and DMMI groups.

A significant increase (P < 0.05) in the percentage of HbA1c in all patients (DM, MI, and DMMI groups) compared with the control.

Lipid profile parameters and atherogenic index were significantly (P < 0.05) higher in all patients than healthy individual.

Serum Osteoprotegerin (OPG) levels elevates significantly (P < 0.05) in all patients compared with the control group, the MI patients showed the highest OPG levels in all patients.

Also there were no significant difference between males and females in serum OPG levels.

In DM and DMMI groups serum OPG levels were significantly higher in elderly patients (aged more than 60 years) than patients aged 40-50 years.

In conclusion, serum OPG levels were higher in diabetic patients suffering from myocardial infarction, so this parameter could be a risk marker for MI in diabetic patients.