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Tumor necrosis factor alpha, interleukin 6, intracellular adhesion molecule-1 and uric acid levels in chronic heart failure
العناوين الأخرى
معامل تنخر الورم ألفا و إنترلوكين-6 و جزئ الالتصاق-1 بين الخلايا و حمض البوليك في هبوط القلب المزمن
المؤلفون المشاركون
Muhammad, Umniyah Abd al-Munim
Bakhit, Madihah Yunus
Maghribi, Muhammad Husam al-Din Hasan
al-Hanafi, Nur al-Din
Faysal, Muhammad
المصدر
العدد
المجلد 28، العدد 1 (31 يناير/كانون الثاني 2004)، ص ص. 1-10، 10ص.
الناشر
تاريخ النشر
2004-01-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Chronic heart failure is a model of systemic hypoxia This hypoxia is associated with activation of xanthine oxidase resulting in hyperuricemia, leucocytes and endothelial cell activation.
Circulating markers of inflammation include Tumor necrosis factor alpha, (TNF-a) interleukin 6,(IL-6) as well as Intracellular adhesion molecule-1 (ICAM-1) were measured, in addition to kidney, liver function tests and serum uric acid.
This study was conducted on forty patients with chronic heart failure class IV.
All the patients were under furosemide and digoxin therapy, the patients also received allopurinol 300 mg/day for one month.
Twenty healthy subjects were included as a control group (group I).
Patients were classified into 2 groups, group II: patients before allopurinal therapy and group III: the same patients one month after therapy.
Mean value of serum uric acid showed significant elevation in group II compared to controls and to patients group (III) (P<0.001 for both).
Mean values of TNF-a, 1L-6 and ICAM-1 revealed significant elevation in patient groups (II, III) before and after therapy compared to controls (P<0.001 for each).
In patients groups after therapy, TNF-a IL-6 and ICAM-1 showed significant reduction compared to patients group before therapy (P<0.001, <0.05 and<0.001 respectively).
Ejection fraction value (%) in patient groups before and after therapy (groups II, III) showed statistically insignificant reduction compared to controls (group I).
We concluded that: 1- There was strong association between hyperuricemia TNF-a, IL-6 and ICAM-1 in chronic heart failure.
These markers may play a role in the development and progression of heart failure through cardiac function impairment.
2- Low dose allopurinal therapy may have a beneficial effect for patients with chronic heart failure through inhibition of xanthine oxidase activity, so we suggest the following: 1- Inhibition of the synthesis, release or function of these cytokines might benefit the heart failure patients by using anticytokine therapy.
2- Inhibition of xanthine oxidase activity by long term high dose of allopurinol therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Hanafi, Nur al-Din& Maghribi, Muhammad Husam al-Din Hasan& Bakhit, Madihah Yunus& Muhammad, Umniyah Abd al-Munim& Faysal, Muhammad. 2004. Tumor necrosis factor alpha, interleukin 6, intracellular adhesion molecule-1 and uric acid levels in chronic heart failure. Assiut Medical Journal،Vol. 28, no. 1, pp.1-10.
https://search.emarefa.net/detail/BIM-53180
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Hanafi, Nur al-Din…[et al.]. Tumor necrosis factor alpha, interleukin 6, intracellular adhesion molecule-1 and uric acid levels in chronic heart failure. Assiut Medical Journal Vol. 28, no. 1(January 2004), pp.1-10.
https://search.emarefa.net/detail/BIM-53180
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Hanafi, Nur al-Din& Maghribi, Muhammad Husam al-Din Hasan& Bakhit, Madihah Yunus& Muhammad, Umniyah Abd al-Munim& Faysal, Muhammad. Tumor necrosis factor alpha, interleukin 6, intracellular adhesion molecule-1 and uric acid levels in chronic heart failure. Assiut Medical Journal. 2004. Vol. 28, no. 1, pp.1-10.
https://search.emarefa.net/detail/BIM-53180
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p.9-10
رقم السجل
BIM-53180
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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