Cytokine pattern In peripheral blood of early and chronic rheumatoid arthritis
المؤلفون المشاركون
Fahmi, Husam Mustafa
Rifat, Majid Muhammad
al-Shishtawi, Nihal Ibrahim
المصدر
Egyptian Rheumatology and Rehabilitation
العدد
المجلد 28، العدد 2 (30 إبريل/نيسان 2001)، ص ص. 377-390، 14ص.
الناشر
الجمعية المصرية للروماتيزم و التأهيل
تاريخ النشر
2001-04-30
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الموضوعات
الملخص EN
Objective: In rheumatoid arthritis (RA), a T (helper) 1 Th1 cytokine profile (interleukin-2, interferon-?, tumor necrosis factor-?) has been described to be dominant over Th2 cytokines (IL-4, 5, 13, 10) in peripheral blood.
This profile is not always fixed and it changes with disease activity, but whether it can change over time is not well known.
We investigated Th1 (INF-?)/ Th2 (IL-10) cytokine balance in early and chronic RA patients for better understanding of the relation of cytokine balance to disease duration and activity.
Material: Twenty chronic RA patients and twenty early RA patients of less than one-year disease duration were evaluated for disease activity.
INF-? and IL-10 were assessed in peripheral blood by stimulated mononuclear cells and ELISA techniques in patients and in twenty healthy controls.
Results: Early RA patients were characterized by a significant elevation of INF-? (p<0.001) that correlated with disease activity, and INF?/IL-10 ratio was 4.7.
On the other hand, chronic RA patients were characterized by a significant elevation of IL-10 (p<0.001), which correlated with disease activity and duration, and INF?/IL10 ratio was 1.45.
Conclusion: There was a significant difference in the cytokine pattern between early and established RA cases that probably reflects differences in the pathogenesis and consequently affects diagnosis and therapeutic interventions according to the phase of the disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rifat, Majid Muhammad& al-Shishtawi, Nihal Ibrahim& Fahmi, Husam Mustafa. 2001. Cytokine pattern In peripheral blood of early and chronic rheumatoid arthritis. Egyptian Rheumatology and Rehabilitation،Vol. 28, no. 2, pp.377-390.
https://search.emarefa.net/detail/BIM-53214
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rifat, Majid Muhammad…[et al.]. Cytokine pattern In peripheral blood of early and chronic rheumatoid arthritis. Egyptian Rheumatology and Rehabilitation Vol. 28, no. 2 (Apr. 2001), pp.377-390.
https://search.emarefa.net/detail/BIM-53214
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rifat, Majid Muhammad& al-Shishtawi, Nihal Ibrahim& Fahmi, Husam Mustafa. Cytokine pattern In peripheral blood of early and chronic rheumatoid arthritis. Egyptian Rheumatology and Rehabilitation. 2001. Vol. 28, no. 2, pp.377-390.
https://search.emarefa.net/detail/BIM-53214
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 388-391
رقم السجل
BIM-53214
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر