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Soluble Fas as an apoptotic marker in myocardial infarction, the outcome and its relation to high risk clinical features
العناوين الأخرى
كدليل للموت المبرمج في الجلطة القلبية المحصلة و علاقته بالمظاهر الإكلينيكية شديدة الخطورة Soluble Fas
المؤلفون المشاركون
Abd al-Munim, Ala al-Din E.
Ashri, Mahmud Ali Mahmud
Izz al-Din, Azzah Muhammad
Ali, Ilham Abd al-Sami
المصدر
العدد
المجلد 28، العدد 1 (31 يناير/كانون الثاني 2004)، ص ص. 135-144، 10ص.
الناشر
تاريخ النشر
2004-01-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
- القلب
- الغدد الصماء
- الأمراض
- أمراض القلب التاجية
- توقف القلب
- قصور القلب
- مرض السكري
- اضطرابات الدورة الدموية
- ارتفاع ضغط الدم
- موت الخلية المبرمج
الملخص EN
Apoptosis contributes to myocardiocyte loss in cardiac disease and may be a major determinant for the development of early symptomatic heart failure (HF).
This study was designed to detect the impact of apoptosis on prognosis and clinical outcome in patients with myocardial infarction (MI) and its relation to the other risk factors for coronary artery disease.
Forty patients (twenty two males, eighteen females) with mean age 53.88±1.39 years diagnosed as MI on the basis of electrocardiographic and enzymatic changes in addition to the clinical symptoms and signs.
Twenty-two were smokers.
Fifteen healthy volunteers were chosen as a control group.
Patients, group was classified according to: A) infarct size (extensive Ml 62.5%, localized MI 37.5%).
B) Presence or absence of heart failure (MI with HF 67.5%, MI without HF 32.5%).
C) Presence or absence of diabetes mellitus (DM) (MI with DM 47.5%, MI without DM 52.5%).
D) Presence or absence of hypertension (HTN) (MI with HTN 47.-5%, MI without HTN 52.5%).
For every participant, history and clinical examination paying special attention to vital signs and cardiopulmonary examination, as well as resting electrocardiogram (ECG) looking for the changes of MI were done.
In addition, the following laboratory investigations: serum sugar, total cholesterol, triglycerides, soluble Apo-l/Fas, homocysteine and nitric oxide (NO) concentrations in serum were assessed.
The serum levels of soluble Fas, homocysteine and nitric oxide (NO), were significantly higher in MI patients than in the controls (P<0.001).
As regard serum levels of soluble Fas in patients with MI, there were significantly higher values in patients with extensive lesions and in those associated with HF in comparison to patients with localized lesions and patients not associated with HF (P<0.001) Serum leveLof homocysteine was significantly higher in normotensive patients with MI and in non-diabetic patients with MI when compared with MI patients associated with hypertension or diabetes mellitus (P<0.05, <0.001 respectively).
Serum level of NO was significantly higher in normotensive patients with MI than in hypertensive patients with MI (P<0.001), it was also significantly higher in patients with localized MI than in patients with extensive MI (P<0.001) and in patients with compensated heart than in patients with symptomatic HF (P<0.001).
We concluded that soluble Fas as a marker of myocardial apoptosis is strongly associated with and may be a major determinant of unfavorable early symptomatic post-infarction HF and is related to the size of MI.
Homocysteine acts as independent risk factor for atherosclerotic cardiovascular events and the decreased level of NO is associated with increased risk for development of atherosclerosis, HTN and symptomatic left ventricular dysfunction (LV.dysfunction).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ali, Ilham Abd al-Sami& Izz al-Din, Azzah Muhammad& Ashri, Mahmud Ali Mahmud& Abd al-Munim, Ala al-Din E.. 2004. Soluble Fas as an apoptotic marker in myocardial infarction, the outcome and its relation to high risk clinical features. Assiut Medical Journal،Vol. 28, no. 1, pp.135-144.
https://search.emarefa.net/detail/BIM-53369
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ali, Ilham Abd al-Sami…[et al.]. Soluble Fas as an apoptotic marker in myocardial infarction, the outcome and its relation to high risk clinical features. Assiut Medical Journal Vol. 28, no. 1(January 2004), pp.135-144.
https://search.emarefa.net/detail/BIM-53369
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ali, Ilham Abd al-Sami& Izz al-Din, Azzah Muhammad& Ashri, Mahmud Ali Mahmud& Abd al-Munim, Ala al-Din E.. Soluble Fas as an apoptotic marker in myocardial infarction, the outcome and its relation to high risk clinical features. Assiut Medical Journal. 2004. Vol. 28, no. 1, pp.135-144.
https://search.emarefa.net/detail/BIM-53369
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p.142-144
رقم السجل
BIM-53369
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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