Circulating soluble intercellular adhesion molecule-1, hyaluronan receptor and leucocyte function antigen-1 in childhood arthritis : correlation with disease activity

الملخص EN

Objective: To measure circulating levels of soluble intercellular adhesion molecule-1 (ICAM-1), Hyaluronan receptor (HR) and leucocyte function antigen-1 (LFA-1) in children with systemic juvenile rheumatoid arthritis (JRA), juvenile systemic lupus erythematosus (JSLE) and rheumatic fever (RF) and to evaluate their correlation with disease activity variables.

Methods: Serum levels of ICAM-1, HR and LFA-1 were measured with two colar immunofluorescent staining on FAC Scan analyser in 44 patients and 16 healthy controls.

Results: ICAM-1 and HR were highly significantly increased in systemic JRA, JSLE and RF as compared with controls while LFA-1 was highly significantly increased in systemic JRA and RF as compared with JSLE and controls.

There was a positive significant correlation between ICAM-1 and fever and ESR in systemic JRA.

In JSLE, ICAM-1 showed an insignificant correlation with laboratory parameters of disease activity and a significant relation with alopecia (p < 0.05) In rheumatic fever ICAM-1 was directly correlated with tenderness score and all studied laboratory parameters of disease activity.

Other adhesion molecules showed an insignificant correlation with clinical and laboratory parameters of disease activity in all patients.

Conclusion: ICAM-1 level was elevated in children suffering from systemic JRA, JSLE and R-F.

This may reflect disease status or activity specially in systemic JRA and rheumatic fever suggesting the usefulness of these molecules in the follow up of these diseases.

On the other hand, we could not find any firm evidence that increased levels of HR and LFA-1 reflect active acute phase response and disease activity in different types of the studied arthritides.