Fast quantitative analysis of pharmaceutical products using LIBS-technique

الملخص EN

The application of calibration free laser-induced breakdown spectroscopy for quantitative analysis of materials, illustrated by CF-LIBS applied to a commercially available pharmaceutical product of unknown composition, is presented in this paper .

The LIBS plasma is produced by a 1.06μm pulsed Nd :YAG laser with a pulse duration of 6ns focused onto a pharmaceutical tablet, named ALOCAL in atmospheric pressure.

Such plasma emission spectrum was collected by using a quartz optical fiber connected to a portable Echelle spectrograph equipped with a time gated ICCD-camera.

Spectroscopic analysis of plasma evolution of laser produced plasma has been investigated using time- resolved laser-induced breakdown spectroscopy(LIBS).In particular, the electron density, and the temperature of the plasma are reported as a functions of its decay time.

The electron temperature Te and density Ne were evaluated using the emission intensity and Stark broadening.

Four elements Al, Mg, C, and Ca were appeared in the obtained spectra using software spectrum analyzer.

Utilizing the algorithm, the Al, Mg, C, and Ca relative concentrations in the sample are determined using the CF-LIBS techniques and were 0.241, 0.167, 0.059 and 0.083 respectively.-