The value of soluble transferrin receptor in early diagnosis of iron deficiency anemia in chronic renal failure
العناوين الأخرى
قيمة مستقبل الترانسفيرين الذائب في مصل الدم في التشخيص المبكر لفقر الدم الناتج عن نقص الحديد في مرض الفشل الكلوي المزمن
المؤلفون المشاركون
Muhammad, Umniyah Abd al-Munim
al-Shadhili, Ashraf Anwar
Sulayman, Hamid Ahmad
Ahmad, Suhayr Muhammad
Sad, Halah Samir
المصدر
العدد
المجلد 27، العدد 2 (31 مايو/أيار 2003)، ص ص. 37-46، 10ص.
الناشر
تاريخ النشر
2003-05-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Decreased erythropoietin (EPO) production is the main pathogenic factor of anemia in chronic renal failure (CRF).
Iron deficiency is the most common cause of EPO resistance in dialyzed patients with renal failure.
Subclinical or functional iron deficiency is difficult to diagnose in these patients.
Aim: This study was designed to determine the sensitivity and specificity of serum iron, transferrin, ferritin and soluble serum transferrin receptor (sTFR) in iagnosis of iron deficiency in chronic renal failure and the efficacy of recombinant human EPO (rHuEPO) treatment.
Patients: This study was conducted on 70 patients with CRF divided into three groups: group (A) CRF patients predialysis (30 cases), group (B) CRF patients on regular dialysis > 5 years (30 cases), and group (C) CRF patients on dialysis and rHuEPO treatment with parentral iron supplementation (10 cases).
Twenty healthy individuals age and sex matched were included as controls.
Methods: Peripheral hemogram, serum urea and creatinine, serum iron (SI) and total iron binding capacity (TIBC), serum ferritin, serum transferrin and (sTFR) were done for both patients and control groups.
Results: There was highly significant reduction of RBCs, hemoglobin (Hb) and hematocrit (Hct) in different patients groups compared to controls; (P<0.001) for each.
Serum iron (SI) was insignificantly reduced in groups A and B compared to controls while it was significantly increased in group C (P<0.05).
Serum transferrin was significantly reduced in all patients groups compared to controls (P<0.001) for each.
Serum ferritin and sTFRwere significantly increased in both group A and B(P<0.001) for each, while in group C, there was significant increase in serum ferritin (P<0.01) and no significant difference in sTFR level compared to controls.
Conclusion: sTFR is a sensitive (sensitivity 93%) and specific (specificity 100%) indicator for identifying iron deficiency and assessing the effect of rHuEPO treatment in CRF patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sulayman, Hamid Ahmad& Ahmad, Suhayr Muhammad& al-Shadhili, Ashraf Anwar& Muhammad, Umniyah Abd al-Munim& Sad, Halah Samir. 2003. The value of soluble transferrin receptor in early diagnosis of iron deficiency anemia in chronic renal failure. Assiut Medical Journal،Vol. 27, no. 2, pp.37-46.
https://search.emarefa.net/detail/BIM-54243
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sulayman, Hamid Ahmad…[et al.]. The value of soluble transferrin receptor in early diagnosis of iron deficiency anemia in chronic renal failure. Assiut Medical Journal Vol.27, No.2(May, 2003), pp.37-46.
https://search.emarefa.net/detail/BIM-54243
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sulayman, Hamid Ahmad& Ahmad, Suhayr Muhammad& al-Shadhili, Ashraf Anwar& Muhammad, Umniyah Abd al-Munim& Sad, Halah Samir. The value of soluble transferrin receptor in early diagnosis of iron deficiency anemia in chronic renal failure. Assiut Medical Journal. 2003. Vol. 27, no. 2, pp.37-46.
https://search.emarefa.net/detail/BIM-54243
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Text in English, abstracts in Arabic & English
رقم السجل
BIM-54243
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر