Arginine vasopressin and prolactin hormones as neuroendocrine immune mediators in primary fibromyalgia syndrome

الملخص EN

Objective : evaluation of the neuroendocrine mechanisms specially hypothalamic-pituitary adrenal axis (HPA) by measuring Arginine vasopressin hormone (AVP) and prolactin levels to detect their role in the etiopathogenesis of primary fibromyalgia syndrome (PMS) and their relations to clinical parameters of the disease.

Methodology : Twenty one female patients with primary fibromyalgia syndrome (group I) and ten apparently normal individuals who served as a control group (group II) were enrolled in our study.

A full detailed history and clinical assessment were done.

Rheumatoid factor, thyroid stimulating hormone and erythrocyte sedimentation rate were within normal values.

Arginine vasopressin and prolactin hormones level were assayed.

Results : There was a highly significant increase in prolactin level in group I than group II while there was no significant difference as regard Arginine vasopressin hormone either corrected (AVPc) or non-corrected values (AVPn) between groups I and II.

There was no significant correlation between disease activity and Arginine vasopressin and prolactin hormones.

Conclusion : this study revealed that neuroendocrine mechanism has no role in the etiopathogenesis of primary fibromyalgia syndrome.

Further study is needed to evaluate the role of peripheral theory (metabolic abnormalities or structural abnormalities of muscle fibers) as implicated in the etiopathogenesis of primary fibromyalgia syndrome.