Tumor necrosis factor alpha, interleukin-10 and nitric oxide in patients with type 1 diabetes mellitus and their association with glycemic control and some complications of the disease
العناوين الأخرى
معامل تنكرز الورم، انترليوكين-10 و أكسيد النيتريك في داء البول السكري النوع الأول و علاقتهم بانضباط مستوى السكر و بعض مضاعفات المرض
المؤلفون المشاركون
Bakhit, Madihah Yunus
Sayyid, Rasha
al-Tahtay, Mahmud
al-Jundi, Salwa Salah
Jalal, Sharif Hilmi
المصدر
العدد
المجلد 27، العدد 2 (31 مايو/أيار 2003)، ص ص. 127-144، 18ص.
الناشر
تاريخ النشر
2003-05-31
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الموضوعات
الملخص EN
Type-1 diabetes mellitus is a disease that results from autoimmune destruction of insulin producing B-cells.
The autoimmune response against B-cells is believed to result from a disorder of immune regulation.
According to this concept tumor necrosis factor alpha (TNF-a), interleukin-10 (IL-10), nitric oxide (NO), urinary albumin excretion rate (UAER) and HbAIc in addition to serum glucose, kidney and liver Junction tests as well as lipogram were studied in sixty eight type-1 diabetic patients.
Twelve healthy subjects were included as a control group According to disease duration patients were classified into three groups: group J (30 cases) patients with disease duration less than 5 years, group II (22 cases) patients with disease duration 5-10 years and group III (16 cases) patients with disease duration> 10 years.
Also patients were classified according to UAER into 3 groups: group A (30 cases) normoalbuminuric patients UAER<20 pg/min.
group B (35 cases) microalbuminuric patients UAER 20-200pg/min.
group C (3 cases) macroalbuminuric patients UAER>200 pg/min.According to HbAIc levels.patients were classified into controlled group (HbAcK 6%) 20 patients and uncontrolled group(HbAlc> 6 %)48 patients.
In whole patients group mean values of HbAIc, TNF-a and UAER showed significant elevations compared to controls (P<0.001,0.001 and 0.05 respectively), while IL-10 revealed significant reduction.
(P<0.001): NO mean value showed statistically insignificant elevation.
Mean values of HbAIc in groups I, II, III, A, B revealed significant elevations compared to controls (P<0.001 for all) also in group III versus group I (P<0.05) and in group B versus A (P<0.05).
TNF-a showed significant elevation in groups 1, II, III in comparison with controls (P<0.001 for all).
While mean value of IL-10 showed significant reduction in groups I, III compared to controls (P<0.01, P<0.001 respectively) also in group III versus group I, II (P<0.01 for both).
NO and UAER showed significant elevations in group HI compared to controls (P<0.05 andP<0.01 respectively).
NO levels showed significant elevation in groups I&III compared to group 11 (P<0.05 for both).
UAER in group III revealed significant elevation versus groups I and II (P<0.01, P<0.001 respectively).
In normoalbuminuric and microalbuminuric groups (A, B) TNF-a showed significant elevation compared to controls (P<0.001 for both).
IL-10 mean value showed significant reduction in groups A & B compared to controls (P<0.001 for both).
NO levels revealed no significant differences.
In uncontrolled group, level of IL 10 was significantly low,while UAER was significantly high(p<0,05 for both).
TNF-a and NO showed no signifigant difference between controlled and uncontrolled groups.
Positive correlations were found between TNF-a and serum glucose and HbAIc, also negative correlations were found between IL-10 and serum glucose, HBAIc, cholesterol, triglycerides and LDL-c.
NO showed positive correlation with UAER level.
From this study we concluded that increased TNF-a (proinflammatory cytokine ofThl ) and decreased IL-10 levels (type 2 cytokine of Th2) may play a role in the pathogenesis of type-1 diabetes mellitus.
TNF-a and IL-10 may be a predictor of glycemic control.
Increased NO level may play a role in the pathogenesis and complications of diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Jundi, Salwa Salah& Bakhit, Madihah Yunus& Jalal, Sharif Hilmi& Sayyid, Rasha& al-Tahtay, Mahmud. 2003. Tumor necrosis factor alpha, interleukin-10 and nitric oxide in patients with type 1 diabetes mellitus and their association with glycemic control and some complications of the disease. Assiut Medical Journal،Vol. 27, no. 2, pp.127-144.
https://search.emarefa.net/detail/BIM-54401
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bakhit, Madihah Yunus…[et al.]. Tumor necrosis factor alpha, interleukin-10 and nitric oxide in patients with type 1 diabetes mellitus and their association with glycemic control and some complications of the disease. Assiut Medical Journal Vol.27, No.2(May, 2003), pp.127-144.
https://search.emarefa.net/detail/BIM-54401
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Jundi, Salwa Salah& Bakhit, Madihah Yunus& Jalal, Sharif Hilmi& Sayyid, Rasha& al-Tahtay, Mahmud. Tumor necrosis factor alpha, interleukin-10 and nitric oxide in patients with type 1 diabetes mellitus and their association with glycemic control and some complications of the disease. Assiut Medical Journal. 2003. Vol. 27, no. 2, pp.127-144.
https://search.emarefa.net/detail/BIM-54401
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Text in English, abstracts in Arabic & English
رقم السجل
BIM-54401
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر