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Modulation of the pharmacological properties of meloxicam by octreotide in rats
المؤلفون المشاركون
al-Awdan, Sali Abd al-Wanis
al-Shafi, Nirmin
Salam, Umar A.
al-Iraqi, Wafa Ibrahim
Kinawy, Sana Abd al-Baqi
المصدر
Journal of Saudi Chemical Society
العدد
المجلد 19، العدد 2 (31 مارس/آذار 2015)، ص ص. 123-132، 10ص.
الناشر
تاريخ النشر
2015-03-31
دولة النشر
السعودية
عدد الصفحات
10
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الكيمياء
الموضوعات
الملخص EN
The purpose of this study was to investigate the anti-inflammatory, analgesic, antipyretic and antiulcer properties of somatostatin analogue octreotide (10 and 100 lg/kg) and its influence on the effect of NSAID meloxicam (1 and 2 mg/kg) in rats.
Carrageenan-induced rat paw oedema was used as an acute anti-inflammatory model as well as adjuvant-induced arthritis as a chronic model.
Hot plate test on rats and acetic acid (0.6%) writhing test were used as acute analgesic models while the plantar test using an infrared beam directed to the paw of arthritic rats was used as a chronic analgesic model.
Antipyretic effect was evaluated using Brewer’s yeast (44%) induced hyperthermia in rats while pylorus ligation was used as a model to evaluate the ulcerogenic effects.
Meloxicam, octreotide and their combinations administered subcutaneously showed anti-inflammatory effects in both acute and chronic models.
Only the high doses of meloxicam and octreotide showed significant analgesic effect in the hot plate test, while all doses showed significant analgesic effects in the acetic acid-induced writhing test and in the plantar test.
In yeast-induced hyperthermia, only meloxicam has an antipyretic effect.
Meloxicam resulted in profound gastric lesions and exerted deleterious effects on the gastric mucosa in pyloric-ligated rats.
Octreotide did not cause any harmful effect on the gastric mucosa, besides; octreotide attenuated the harmful ulcerogenic effects of meloxicam when administered in combination with it.
Both meloxicam and octreotide and their combination significantly decreased the malondialdehyde (MDA) content in the arthritic rats indicating their antioxidant effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Awdan, Sali Abd al-Wanis& al-Shafi, Nirmin& Salam, Umar A.& al-Iraqi, Wafa Ibrahim& Kinawy, Sana Abd al-Baqi. 2015. Modulation of the pharmacological properties of meloxicam by octreotide in rats. Journal of Saudi Chemical Society،Vol. 19, no. 2, pp.123-132.
https://search.emarefa.net/detail/BIM-545432
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Awdan, Sali Abd al-Wanis…[et al.]. Modulation of the pharmacological properties of meloxicam by octreotide in rats. Journal of Saudi Chemical Society Vol. 19, no. 2 (Mar. 2015), pp.123-132.
https://search.emarefa.net/detail/BIM-545432
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Awdan, Sali Abd al-Wanis& al-Shafi, Nirmin& Salam, Umar A.& al-Iraqi, Wafa Ibrahim& Kinawy, Sana Abd al-Baqi. Modulation of the pharmacological properties of meloxicam by octreotide in rats. Journal of Saudi Chemical Society. 2015. Vol. 19, no. 2, pp.123-132.
https://search.emarefa.net/detail/BIM-545432
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 130-132
رقم السجل
BIM-545432
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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