Endothelial dysfuntion in insulin resistance syndrome
العناوين الأخرى
خلل في البطانة الوعائية الفارشة في المتلازمة المقاومة للأنسولين
المؤلفون المشاركون
Muhammad, Umniyah Abd al-Munim
Shahwan, Muhammad Munir
Maghribi, Muhammad Husam al-Din Hasan
Idward, Hanan
المصدر
العدد
المجلد 27، العدد 1 (31 يناير/كانون الثاني 2003)، ص ص. 77-88، 12ص.
الناشر
تاريخ النشر
2003-01-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الموضوعات
الملخص EN
The objective of this study was to determine and correlate the plasma level of Tumour necrosis factor-a (TNF-a) and Endothelin-l (ET-l) in type 2 diabetic patients with different types of obesity and to find out their correlation with the degree of glycaemic control and serum lipid levels.
The study was performed on three groups of non smoker, type 2 diabetic patients, they were divided into 15 lean patients, 15 gynoid obese patients and 15 android obese patients.
Plasma levels of fasting and 2- hours postprandial glucose, cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol were determined Plasma levels of TNF-a and ET-l were also determined.
The data were analyzed according to student's "t" test and Pearson's correlation coefficient.
TNF-a plasma levels showed significant elevation in android obese diabetics as compared to lean diabetics, due to increased expression from adipose tissue (in the visceral fat).
TNF-a levels showed a significant (P<0.01) positive correlation with both BM1 and ET-l in android obese group only.
Plasma levels of ET-l were also found to be significantly (P<0.01) high in android obese diabetics as compared to lean diabetics.
This was attributed to interaction between TNF-a (present in high levels in android obese patients) and insulin, leading to elevation of ET-1 level.
ET-1 levels showed a significant (P<0.01) positive correlation with BMI in android obese patients only.
We concluded that the insulin resistance syndrome (IRS) is associated with endothelial dysfunction (it is possible that endothelial dysfunction is caused by some other features of IRS or could itself be a common antecedent mechanism) and TNF-a and ET-1 could be a marker to both.
Our data suggest an important role for TNF-a in the pathogenesis of human insulin resistance syndrome as occur in android obesity and type 2 diabetic patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Maghribi, Muhammad Husam al-Din Hasan& Shahwan, Muhammad Munir& Idward, Hanan& Muhammad, Umniyah Abd al-Munim. 2003. Endothelial dysfuntion in insulin resistance syndrome. Assiut Medical Journal،Vol. 27, no. 1, pp.77-88.
https://search.emarefa.net/detail/BIM-54713
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maghribi, Muhammad Husam al-Din Hasan…[et al.]. Endothelial dysfuntion in insulin resistance syndrome. Assiut Medical Journal Vol.27, No.1(January, 2003), pp.77-88.
https://search.emarefa.net/detail/BIM-54713
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Maghribi, Muhammad Husam al-Din Hasan& Shahwan, Muhammad Munir& Idward, Hanan& Muhammad, Umniyah Abd al-Munim. Endothelial dysfuntion in insulin resistance syndrome. Assiut Medical Journal. 2003. Vol. 27, no. 1, pp.77-88.
https://search.emarefa.net/detail/BIM-54713
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 88
رقم السجل
BIM-54713
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر