Histopathological and serological study of goitre

الملخص EN

The correlation of histopathology and serology results in patient with goiter.

Accurate detection of thyroid autoantibodies by enzyme linked immunosorbant assay technique namely thyroglobulin antibody, thyroid peroxidase antibody is crucial in the differentiation of autoimmune thyroid disorders from other form of thyroid diseases.

Evaluation of the detection of thyroglobulin antibody and thyroid peroxidase antibody in different thyroid diseases using enzyme linked immunosorbant assay technique.

Eighty patients admitted to Surgical Units of Al-Zahraa Teaching Hospital in Al-Kut from the period between august 2010 to August 2012 they were waiting to do thyroidectomy.

They were chosen nonselective for serological evaluation of above autoantibodies, and correlation of the results with histopathological diagnosis.

Clinical results; Colloid goiter is known cause of hyperthyroidism (5 were colloid goiter out of 10 total hyperthyroid patients ) (50%) , and still common thyroid surgery (60 were colloid goiterout of 80 thyroid surgery) (75%).

Histopathological results; - 58 cases (72.5%) had colloid goiter, 11 patients had Graves' disease (13.75%), and 3 had lymphocytic thyroiditis (3.75%), 8 had thyroid neoplasia (both benign and malignant) (10%).

The serological results; Antibodies results were positive in 7 patients (11%) in colloid goiter (p-> 0.05), 6 patients (66.6%) and 1 patient (33.3%) for Grave’s disease, and lymphocytic thyroiditis respectively (P-< 0.05)., while its all were negative in thyroid neoplasia.

Serum thyroid autoantibodies determination is valuable test in clinical practice of autoimmune thyroid diseases.