Homeostatic model assessment of insulin resistance as a predictor of metabolic syndrome : consequences of obesity in children and adolescents
المؤلفون المشاركون
Barsim, Najla Fathi
Hulwah, Muhammad Ahmad
المصدر
Egyptian Pediatric Association Gazette
العدد
المجلد 63، العدد 1 (31 مارس/آذار 2015)، ص ص. 19-24، 6ص.
الناشر
تاريخ النشر
2015-03-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Obesity and / or insulin resistance have gained increasing attention as the core manifestations of metabolic syndrome.
Objective : To evaluate insulin resistance according to homeostasis model assessment of insulin resistance index HOMA-IR in obese children and adolescents with or without metabolic syndrome at risk of type 2 diabetes mellitus.
Design and subjects : 60 obese children and adolescents were recruited, metabolic syndrome was diagnosed according to the modified WHO criteria adapted for children and adolescents.
Insulin resistance was calculated using the HOMA-IR.
Results : Metabolic syndrome (MS) was found in 42 subjects (70 %), using modified WHO guidelines for diagnosing MS.
On comparing MS-related parameters between the groups with (MS+) and without metabolic syndrome (MS_), median body mass index, waist circumference, waist / height ratio, and blood pressure, total cholesterol and triglyceride were significantly higher in the MS+ group.
Basal insulin level as well as HOMA-IR was also significantly different between MS+ and MS-groups.
The presence of insulin resistance according to HOMA-IR was identified in 53 % of obese children and adolescents.
This HOMA-IR age and sex limit was exceeded by 70 % children in the MS + group, but only by 43 % children in the MS-group (p < 0.001).
HOMA-IR was positively correlated with the majority of anthropometric and biochemical parameters.
The correlation was strongest with body mass index, waist circumference and diastolic blood pressure.
Conclusions : HOMA-IR might be a reliable surrogate measure of insulin resistance and a strong predictor of type 2 diabetes in obese adolescents allowing the development of preventive measures and treatment when needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barsim, Najla Fathi& Hulwah, Muhammad Ahmad. 2015. Homeostatic model assessment of insulin resistance as a predictor of metabolic syndrome : consequences of obesity in children and adolescents. Egyptian Pediatric Association Gazette،Vol. 63, no. 1, pp.19-24.
https://search.emarefa.net/detail/BIM-564915
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Barsim, Najla Fathi& Hulwah, Muhammad Ahmad. Homeostatic model assessment of insulin resistance as a predictor of metabolic syndrome : consequences of obesity in children and adolescents. Egyptian Pediatric Association Gazette Vol. 63, no. 1 (Mar. 2015), pp.19-24.
https://search.emarefa.net/detail/BIM-564915
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barsim, Najla Fathi& Hulwah, Muhammad Ahmad. Homeostatic model assessment of insulin resistance as a predictor of metabolic syndrome : consequences of obesity in children and adolescents. Egyptian Pediatric Association Gazette. 2015. Vol. 63, no. 1, pp.19-24.
https://search.emarefa.net/detail/BIM-564915
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 23-24
رقم السجل
BIM-564915
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر