Non-hodgkin lymphoma in Sudanese children

الملخص EN

Non-Hodgkin Lymphoma is a very heterogeneous lymphoproliferative disease with clinical and histological pattern different from children to adults.

Objective : To characterize the clinical and pathological pattern of Non -Hodgkin`s lymphoma among Sudanese children.

Materials and Methods : This study was undertaken prospectively on paediatric cases (16 years) referred to histopathology department, Radio-Isotope Centre, Khartoum which is the main Centre for cancer management in Sudan from January 2008 to December 2012.

The clinical and demographical data of these patients were recorded.

The H & E stained slides of each case were examined initially, then the confirmed cases of non- Hodgkin`s lymphoma were classified according to the 2008 WHO classification of neoplastic diseases of the haematopoietic lymphoid tissue following immunostaining of sections cut from formalin-fixed, paraffin embedded (FFPE) tissue blocks with the following panel of antibodies:- LCA, CD3, CD5, CD10, CD20, CD23, BCL2, CyclinD1, MUM1,CD15,CD30 andKi67.

Results: Age range was9monthsto 16years.

Fifty percent of the cases occurred between the age 2-5 years and only one case below one year.

Male to female ratio was 1.

6.

Extranodal lymphoma (60 %) was higher than nodal type (40 %).The most commonly affected site was the gastrointestinal tract.

Most of the gastrointestinal lymphoma presented with abdominal mass.

The most common histological type was Burkitt`s lymphoma.

None of the cases were small lymphocytic, follicular or T- cell type.

Bone marrow involvement was in 87.

5 % of the cases at the time of diagnosis.

Conclusion : Burkitt`s lymphoma is the predominant paediatric lymphoma in Sudan.

The majority of the cases presented late with bone marrow involvement.