Design, synthesis, molecular properties and antimicrobial activities of some novel 2(3H) pyrrolone derivatives
المؤلفون المشاركون
Abd al-Salam, Aftab Ahmad
Husayn, Assaf
Mujeeb, Mohd.
Bhandari, Anil
Khan, Shah Alam
المصدر
Journal of Saudi Chemical Society
العدد
المجلد 19، العدد 3 (30 يونيو/حزيران 2015)، ص ص. 340-346، 7ص.
الناشر
تاريخ النشر
2015-06-30
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
In continuation of our research on nitrogen containing heterocyclic compounds to develop potent antimicrobial and antimycobacterial agents, some novel 2(3H) pyrrolone derivatives were synthesized.
We report here two new series of 3-Arylidene-5-(4-chloro/methyl phenyl)-2(3H) pyrrolones (14–19) and 3-Arylidene-5-(4 chloro/methyl phenyl)-1-benzyl-2(3H) pyrrolones (20–25) prepared by reacting intermediate furanone compounds (6–13) with ammonia gas and benzylamine respectively.
The structures of the title compounds were established on the basis of IR, 1H NMR, mass spectral data and elemental analysis results.
All the synthesized pyrrolone derivatives were evaluated for their possible antibacterial, antifungal and antitubercular activities.
Among all the synthesized compounds, compound 17, 3-(4-Hydroxy-3-methoxybenzylidene)-5-(4-chlorophenyl)-2(3H)-pyrrolone, emerged as a lead compound exhibiting the highest antibacterial, antifungal and antitubercular activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Mycobacterium tuberculosis with 6.25 lg/mL MIC (minimum inhibitory concentration).
Molecular properties of pyrrolones were also calculated by Molinspiration software for drug likeness.
It was observed that all 2(3H) pyrrolones (14–19) obeyed Lippinski’s rule of five and expected to be orally active.
They were also found to be more potent antimicrobial agents than 1-benzyl-2(3H) pyrrolones (20–25) and their activity was comparable with standard drugs such as Ciprofloxacin, Ketoconazole and Streptomycin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Salam, Aftab Ahmad& Husayn, Assaf& Khan, Shah Alam& Mujeeb, Mohd.& Bhandari, Anil. 2015. Design, synthesis, molecular properties and antimicrobial activities of some novel 2(3H) pyrrolone derivatives. Journal of Saudi Chemical Society،Vol. 19, no. 3, pp.340-346.
https://search.emarefa.net/detail/BIM-566527
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khan, Shah Alam…[et al.]. Design, synthesis, molecular properties and antimicrobial activities of some novel 2(3H) pyrrolone derivatives. Journal of Saudi Chemical Society Vol. 19, no. 3 (2015), pp.340-346.
https://search.emarefa.net/detail/BIM-566527
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Salam, Aftab Ahmad& Husayn, Assaf& Khan, Shah Alam& Mujeeb, Mohd.& Bhandari, Anil. Design, synthesis, molecular properties and antimicrobial activities of some novel 2(3H) pyrrolone derivatives. Journal of Saudi Chemical Society. 2015. Vol. 19, no. 3, pp.340-346.
https://search.emarefa.net/detail/BIM-566527
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 345-346
رقم السجل
BIM-566527
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر