Monitoring of the antiviral potential of bee venom and wax extracts against adeno-7 (DNA)‎ and rift valley fever virus (RNA)‎ viruses models

الملخص EN

This study monitored the antiviral potential of bee venom and four wax extracts, ethanol white and black beeswax (EWW/EBW) and acetone white and black beeswax (AWW/ABW) extracts.

Two different virus models namely Adeno-7 as DNA model and RVFV as RNA virus models.

End point calculation assay was used to calculate virus depletion titer.

The depletion of viral infectivity titer of ABW to Adeno-7 virus showed strong antiviral activity recorded a depletion of viral infectivity titer (1.66 log (10) / ml) that gave equal action with bee venom and more than interferon IFN (1 log (10) / ml).

On the other hand, antiviral activity of EBW showed a moderate potential, while AWW showed no antiviral activity.

Finally EWW showed synergetic activity against Adeno-7 virus activity.

Thus, activity of wax extracts to RVFV was arranged in order of IFN > bee venom > AWW & EBW > EWW and ABW recorded 3.34, 0.65, 0.5, 0.34 respectively.

It is the first time to study the beeswax effect against DNA and RNA virus’ models; acetone black beeswax recorded a depletion titer 1.66 log (10) / ml