Serum and synovial fluid interleukin-15 level in rheumatoid arthritis
العناوين الأخرى
مستوى الإنترلوكين-15 في المصل و السائل السينوفي في مرض الروماتويد المفصلي
المؤلفون المشاركون
Ibrahim, Maha Atwah Muhammad
Rashad, Suniya Muhammad
Muhammad, Sumayyah Abd al-Rahman
Uthman, Usamah Bakr Sadiq
Thumayrk, Dua
المصدر
العدد
المجلد 26، العدد 2 (30 إبريل/نيسان 2002)، ص ص. 33-44، 12ص.
الناشر
تاريخ النشر
2002-04-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الموضوعات
الملخص EN
In a trial to a assess the value of interleukin-15 (IL-15) as an important cytokine implicated in the pathogenesis of rheumatoid arthritis (RA), and its correlation with disease activity, its level was measured in sera and synovial fluids of 44 RA patients, 22 were in the active stage of the disease (with synovial effusion} and the other 22 were in remission, (12 in the subacute and 10 in the chronic stage of the disease) out of all patients, 30 were seropositive and 14 were seronegative for rheumatoidfactor (RF).
Values of serum IL-15 of RA patients were compared with those of 12 apparently healthy age and sex matched controls, while values of synovial fluid (SF) IL-15 in the active RA patients were compared with IL-15 levels in SF of 12 osteoarthritic patients (OA) as a control group.
The study revealed undetectable serum IL-15 levels in normal controls and 15 RA patients [5 in the active stage and 10 in remission (7 in the chonic and 3 in the subacute stage].
In comparing RA patient groups, it was found that serum IL-15 was significantly higher in the active group than in the remission group (P<0.05) and in the subacute than in the chronic stage ofRA(P<0.01).
In paired samples (n=22) of sera and SF from RA patients, IL-15 levels were higher in the SF than in sera (p<0.001), in addition, the SF levels of IL-15 in RA patients significantly exceeded those present in OA (P<0.001).
Serum IL-15 was found to be positively correlated with synovial fluid IL-15 in active RA patients (r=0.703, p<0.001).
Serum 1L-15 was higher in RA patients with positive rheumatoid factor (p<0.05), also a significant positive correlation was detected between synovial fluid IL-15 and rheumatoid factor inactive RA patients (r=0.719, p<0.01).
C-reacttve protein (CRP) was positively correlated with synovial fluid IL-15 in the active group ofRA (r-0.501, p<0.05).
There was a significant positive correlation between serum and synovial fluid IL-15 in active RA on one hand and ESR on the other hand (r=0.623,p<0.01 andr~0.452, p<0.05 respectively), in the same patient group, serum and synovial fluid IL-15 were positively correlated with all clinical parameters of disease activity including: duration of morning stiffness (r=0.464, p<0.05 andr=0.656, p<0.001 respectively), number of swollen joints(r=0.761, P<0.001 and r=0.576, P<0.01 respectively), and number of tender joints (r=0.897, P<0.001 and r=0.611, P<0.01 respectively).
No correlation could be detected between IL-15 levels whether in the serum or the synovial fluid and duration of the disease in RA.
In conclusion a higher concentration cfIL-15 is found mainly in RA synovial fluid.
This locally produced cytokine can contribute to the pathogenesis of RA, also 1L-15 can be used as a parameter of disease activity, in RA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Uthman, Usamah Bakr Sadiq& Muhammad, Sumayyah Abd al-Rahman& Rashad, Suniya Muhammad& Ibrahim, Maha Atwah Muhammad& Thumayrk, Dua. 2002. Serum and synovial fluid interleukin-15 level in rheumatoid arthritis. Assiut Medical Journal،Vol. 26, no. 2, pp.33-44.
https://search.emarefa.net/detail/BIM-56900
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Uthman, Usamah Bakr Sadiq…[et al.]. Serum and synovial fluid interleukin-15 level in rheumatoid arthritis. Assiut Medical Journal Vol.26, No.2(April, 2002), pp.33-44.
https://search.emarefa.net/detail/BIM-56900
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Uthman, Usamah Bakr Sadiq& Muhammad, Sumayyah Abd al-Rahman& Rashad, Suniya Muhammad& Ibrahim, Maha Atwah Muhammad& Thumayrk, Dua. Serum and synovial fluid interleukin-15 level in rheumatoid arthritis. Assiut Medical Journal. 2002. Vol. 26, no. 2, pp.33-44.
https://search.emarefa.net/detail/BIM-56900
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 43-44
رقم السجل
BIM-56900
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر