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The impact of recombinant human erythropoietin treatment on motor impairment in rotenone-induced parkinsonism in rats
المؤلفون المشاركون
Abd al-Halim, Daliyah M.
Abdu, Muhammad
Husayn, Muna A.
المصدر
Suez Canal University Medical Journal
العدد
المجلد 17، العدد 2 (31 ديسمبر/كانون الأول 2014)، ص ص. 117-130، 14ص.
الناشر
تاريخ النشر
2014-12-31
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الموضوعات
الملخص EN
Parkinson’s disease is a neurodegenerative disease mainly characterized by loss of dopaminergic neurons in the substantia nigra pars compacta and their terminals in the striatum.
The development of neuroprotective drugs that slow or delay neurodegeneration became of a considerable interest.
In numerous animal models, exogenously administered EPO exhibits neuroprotective effects.
Aim: The current research investigated the impact of administration of recombinant human EPO (rhEPO) in rotenone parkinsonian rats.
Materials and Methods: Thirty two adult male albino Sprague-Dawly rats were equally and randomly divided into four groups; group 1 the vehicle-treated group, group 2 rotenone-treated group, group 3 treated with rote-none in addition to intranasal rhEPO and group 4 treated with rotenone in addition to intraperitoneal rhEPO.
The motor performance of the rats was evaluated.
Malondialdehyde and reduced glutathione were assayed.
Blood indices were measured.
Histopathology of the substantia nigra was also done.
Results: Results showed that rotenone-treated rats exhibited sig-nificant impairment of motor coordination and marked degeneration of substantia nigra neurons was observed.
Both intranasal and intraperitoneal rhEPO treatment improved the motor deficit and significantly increased the number of neurons in the SNpc.
intraperitoneal rhEPO significantly increased lipid peroxide and significantly affected blood indices.
Conclusion: Our findings suggest that, EPO may have neuroprotective effect in PD.
Systemic rhEPO neuroprotective effects may be attenuated by its adverse effects such as increase of OS in the vascular system and stimulation of erythropoiesis.
Small doses of intranasal EPO may be sufficient to produce neuroprotection with-out affecting erythropoiesis and further researches are required to address the mechanisms of neuroprotective effects of EPO.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Halim, Daliyah M.& Husayn, Muna A.& Abdu, Muhammad. 2014. The impact of recombinant human erythropoietin treatment on motor impairment in rotenone-induced parkinsonism in rats. Suez Canal University Medical Journal،Vol. 17, no. 2, pp.117-130.
https://search.emarefa.net/detail/BIM-576985
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Halim, Daliyah M.…[et al.]. The impact of recombinant human erythropoietin treatment on motor impairment in rotenone-induced parkinsonism in rats. Suez Canal University Medical Journal Vol. 17, no. 2 (Dec. 2014), pp.117-130.
https://search.emarefa.net/detail/BIM-576985
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Halim, Daliyah M.& Husayn, Muna A.& Abdu, Muhammad. The impact of recombinant human erythropoietin treatment on motor impairment in rotenone-induced parkinsonism in rats. Suez Canal University Medical Journal. 2014. Vol. 17, no. 2, pp.117-130.
https://search.emarefa.net/detail/BIM-576985
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 126-130
رقم السجل
BIM-576985
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