Plasma endothelin-1 and thrombomodulin : correlation with extent of pulmonary hypertension in patients with chronic hypoxic pulmonary disease
العناوين الأخرى
علاقة الأندوثلين-1 و الثرومبوديولين بمدى ضغط الدم الرئوي المرتفع في مرضى قلة الأكسجين الرئوي المزمن
المؤلفون المشاركون
Ibrahim, Maha Atwah Muhammad
Farraj, Mahmud Kamil
Bakhit, Madihah Yunus
Ahmad, Suzan Salamah Sayyid
المصدر
العدد
المجلد 25، العدد 4 (31 أكتوبر/تشرين الأول 2001)، ص ص. 31-44، 14ص.
الناشر
تاريخ النشر
2001-10-31
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الموضوعات
الملخص EN
Endothelia is a family of potent vasoconstrictor peptides of vascular endothelial origin, although it has been proposed that the vasoconstrictor effects of endothelin are produced at the local vascular level, increased plasma concentration of endotheline has been identified in cardiovascular disorders The level of the immunoreactive endotheline -l, [a potent endothelial-vasoconstrictor present in pulmonary hypertension (PH), was assayed by measuring its Concentration in plasma and correlates its level with the level of partial pressure of oxygen (PaO) ,and echo parameters of pulmonary hypertension Vie study included forty-seven pulmonary hypertensive patterns secondary to chronic hypoxia due to chronic obstructive pulmonary diseases (COPD) and interstitial pulmonary fibrosis flPF).
They were admitted to chest department.
Assiut University Hospital.
?;."jU-d in the mcrmng afler cm overnight fast h-Jbre n;edt> at :on j>nl after termination of treatment.
The endo'-helin-! level Ml 1.45'0 32 pgml, which was increased compared with normal controls (0.5^0.02), the difference was statistically significant (P<0.0S).
Endothelium! significantly correlated with pulmonary pressure and its degree of severity (r ~ 0.4?I, p < 0.01/ especially among chronic obstructive pulmonary disease patients.
There was significant reduction in the level ofendothelin I after long term oxygen therapy, whereas, the I'evet of endotheiiin-1 did not correlate with the level of PaO.
either before or after oxygen therapy.
Plasma thrombomodulin level was measured to study its pathophysiological significance in pulmonary hypertension secondary to hypoxia Patients with pulmonary hypertension had higher concentrations of thrombomodulin (J5.25 +1.5) than age matched normal controls (4.H±0.S ng/raL P< 0.00/).
There was a significant reduction in thrombomodulin after oxygen therapy Plasma concentrations of thrombomodulin were significantly correlated with time to peak velocity (TPV) as a strong echo parameter of pulmonary hypertension and Its severity, in mild PH thrombomodulin level recorded was 10.40+0.56 ng'mL versus I'5.82+3.08 ng/ml.
among patients with severe pulmonary hypertension.
Moreover, thrombomodulin correlates with Pa02 after oxygen therapy especially with patients of IFF (r - 0.749 p < 0.001).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ibrahim, Maha Atwah Muhammad& Bakhit, Madihah Yunus& Ahmad, Suzan Salamah Sayyid& Farraj, Mahmud Kamil. 2001. Plasma endothelin-1 and thrombomodulin : correlation with extent of pulmonary hypertension in patients with chronic hypoxic pulmonary disease. Assiut Medical Journal،Vol. 25, no. 4, pp.31-44.
https://search.emarefa.net/detail/BIM-57720
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ibrahim, Maha Atwah Muhammad…[et al.]. Plasma endothelin-1 and thrombomodulin : correlation with extent of pulmonary hypertension in patients with chronic hypoxic pulmonary disease. Assiut Medical Journal Vol. 25, no. 4 (2001), pp.31-44.
https://search.emarefa.net/detail/BIM-57720
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ibrahim, Maha Atwah Muhammad& Bakhit, Madihah Yunus& Ahmad, Suzan Salamah Sayyid& Farraj, Mahmud Kamil. Plasma endothelin-1 and thrombomodulin : correlation with extent of pulmonary hypertension in patients with chronic hypoxic pulmonary disease. Assiut Medical Journal. 2001. Vol. 25, no. 4, pp.31-44.
https://search.emarefa.net/detail/BIM-57720
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 43-44
رقم السجل
BIM-57720
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر