Apoptotic properties of polysaccharide isolated from fruiting bodies of medicinal mushroom fomes fomentarius in human lung carcinoma cell line
المؤلفون المشاركون
Kim, Sang Hoon
Jakhar, Rekha
Kang, Sun Chul
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 22، العدد 4 (31 ديسمبر/كانون الأول 2015)، ص ص. 484-490، 7ص.
الناشر
تاريخ النشر
2015-12-31
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Mushrooms are known to complement chemotherapy and radiation therapy by countering the side effects of cancer.
Recently, there has been great interest in isolation of novel bioactive compounds from mushrooms due to their numerous health beneficial effects.
Chemically water-extractable polysaccharide (MFKF-AP1b), with a molecular weight of 12 kDa, was isolated from fruiting bodies of mushroom Fomes fomentarius.
In this research, we investigated the anti-tumor effects of MFKF-AP1b on human lung carcinoma A549 cells.
Results showed that MFKF-AP1b markedly inhibited A549 cell growth in a dose-dependent manner based on the amount of lactate dehydrogenase (LDH) released and morphological alterations.
In addition, MFKF-AP1b induced cellular apoptosis by causing single-stranded DNA breakage, as evidenced by apoptosis assay.
Furthermore, MFKF-AP1b (25–100 lg/ml) significantly induced singlestranded DNA breakage in A549 cells, as shown by comet assay.
Taken together, our results demonstrate that MFKF-AP1b has strong anti-tumor effects mediated through induction of apoptosis.
Therefore, MFKF-AP1b could be useful in lung chemotherapy.
ª 2014 The Authors.
Production and hosting by Elsevier B.V.
on behalf of King Saud University.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Sang Hoon& Jakhar, Rekha& Kang, Sun Chul. 2015. Apoptotic properties of polysaccharide isolated from fruiting bodies of medicinal mushroom fomes fomentarius in human lung carcinoma cell line. Saudi Journal of Biological Sciences،Vol. 22, no. 4, pp.484-490.
https://search.emarefa.net/detail/BIM-577552
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Sang Hoon…[et al.]. Apoptotic properties of polysaccharide isolated from fruiting bodies of medicinal mushroom fomes fomentarius in human lung carcinoma cell line. Saudi Journal of Biological Sciences Vol. 22, no. 4 (2015), pp.484-490.
https://search.emarefa.net/detail/BIM-577552
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Sang Hoon& Jakhar, Rekha& Kang, Sun Chul. Apoptotic properties of polysaccharide isolated from fruiting bodies of medicinal mushroom fomes fomentarius in human lung carcinoma cell line. Saudi Journal of Biological Sciences. 2015. Vol. 22, no. 4, pp.484-490.
https://search.emarefa.net/detail/BIM-577552
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 489-490
رقم السجل
BIM-577552
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر