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Lower HOMA-b values are detected among individuals with variant of E23K polymorphism of potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) gene
المؤلفون المشاركون
Sunita, Raden
Sadiwa, Ahmad Hamim
Farmawati, Arta
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 16، العدد 3 (30 سبتمبر/أيلول 2015)، ص ص. 227-231، 5ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2015-09-30
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Type 2 Diabetes Mellitus (T2DM) is a multifactorial disease involving both genetic and also environmental factors.
Potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) gene, an ATP-sensitive potassium channel-coding gene, contributes to insulin secretion.
Objectives: This research aimed to investigate E23K polymorphism in KCNJ11 gene and insulin secretion in individuals with family history of T2DM (cases) and without family history of T2DM (controls).
Method: This research was a case-control study involving 34 cases and 34 controls.
E23K polymorphism of KCNJ11 was detected with PCR-RFLP.
All of the obtained data were statistically analyzed with T-test, Mann–Whitney U-test, Chi-Square and One-Way ANOVA.
Result: Frequency of AA genotype in individuals with family history of T2DM (41%) was higher than in individuals without family history of T2DM (6%) (p=0.001).
Frequency of A allele in individuals with family history of T2DM (68%) was higher than in individuals without family history of T2DM(38%) (p=0.001).
The risk of A allele in individuals with family history of T2DMwas 3 times higher than in individuals without family history of T2DM (p=0.001, OR 3.38, CI 95% 1.67–6.84).
Homeostasis Model Assessment b (HOMA-b) values of AA genotype (85.44%±39.55) were lower than that of GA (212.20%±79.30) and GG (254.00%±61.98) genotypes (p=0.000).
Conclusion: The risk of having A allele in individuals with family history of T2DM is higher than that in individuals without family history of T2DM.
HOMA-b values of AA genotype are lower than that of GA and GG genotypes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sunita, Raden& Sadiwa, Ahmad Hamim& Farmawati, Arta. 2015. Lower HOMA-b values are detected among individuals with variant of E23K polymorphism of potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) gene. The Egyptian Journal of Medical Human Genetics،Vol. 16, no. 3, pp.227-231.
https://search.emarefa.net/detail/BIM-578101
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sunita, Raden…[et al.]. Lower HOMA-b values are detected among individuals with variant of E23K polymorphism of potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) gene. The Egyptian Journal of Medical Human Genetics Vol. 16, no. 3 ( 2015), pp.227-231.
https://search.emarefa.net/detail/BIM-578101
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sunita, Raden& Sadiwa, Ahmad Hamim& Farmawati, Arta. Lower HOMA-b values are detected among individuals with variant of E23K polymorphism of potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) gene. The Egyptian Journal of Medical Human Genetics. 2015. Vol. 16, no. 3, pp.227-231.
https://search.emarefa.net/detail/BIM-578101
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 231
رقم السجل
BIM-578101
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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