Comparative study for antibacterial activity of some maleamic acid derivatives with some commercial antibiotic

الملخص EN

-Antibacterial activity of the following prepared compounds: Bis-Maleamic acid, Ethylene-Bis-Maleamic acid, 1, 4-phenylene [2,2-diamino-Bis (1, 3, 4-thiadiazol- 5-yl)] Maleamic acid, 4-N (2, 3-dimethyl-1-phenyl pyrazolin-5-one-4-yl) Maleamic acid and 5-methyl-3-sulfanilamido Maleamic acid-isoxazde (Maleamic acid derivatives) were tested against five pathogenic bacterial species.

These werePseudomonasaeruginosa, Escherichiacoli, Salmonellatyphimurium, Proteusmirabilis (Gram negative) and Staphylococcusaureus (Gram positive).

Results showed that all tested compounds have good antibacterial activities comparing with antibiotics Ampicillin, Gentamicin and Tetracycline.

The highest growth inhibition zone diameter for the compounds were (30 mm) against S.

aureus and P.

aeruginosa, (28 mm) against E.

coli, (23 mm) against S.

typhimurium and (14 mm) against P.

mirabilis