Insulin like growth factor 1 as an indicator of growth hormone deficiency
المؤلفون المشاركون
Alawinah, Husayn
Khalidi, Umar
Maita, Jamal
Fugaha, Nifin
Atum, Raid
Shatnawi, Muhammad
المصدر
Journal of the Royal Medical Services
العدد
المجلد 22، العدد 2 (30 يونيو/حزيران 2015)، ص ص. 13-17، 5ص.
الناشر
الخدمات الطبية الملكية الأردنية
تاريخ النشر
2015-06-30
دولة النشر
الأردن
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Objective: Insulin like growth factor 1 is a protein produced by the liver under the effect of Growth hormone.
It is used as a screening test in the evaluation of patients suspected to have growth hormone deficiency.
The aim of the study was to determine the value of Insulin like growth factor 1 level as an Indicator of growth hormone deficiency.
Methods: This is a retrospective simple analytical study of 103 files of clinically diagnosed patients with short stature, was conducted in the period between June 2010 to November 2012 in the endocrine clinic at Queen Rania Al-Abdullah Hospital for Children.
Seventy Patients were males while 33 patients were females, age ranged between 2 and 19 years.
Al of these patients were evaluated clinically, height recorded using a stadiometer.
Baseline routine laboratory studies, thyroid function test, celiac disease screening, and bone age were done for the patients.
Insulin like growth factor 1 level and growth hormone stimulation test were performed for every patient.
Patients with celiac disease, primary hypothyroidism, Turner syndrome, achondroplasia, Chronic liver diseases and malnutrition were excluded from the study.
Results: of the total 103 patients, 70 (68%) were males, 33 (32%) were females.
Mean age was 9.6 years.
There was significant correlation between Insulin like growth factor 1 Level and weight, chronological age, bone age.
While there was no correlation between sex and insulin like growth factor 1.
There was no correlation between Insulin like growth factor 1 and maximum growth hormone level response by growth hormone stimulation test, the correlation r = 0.56, the p value >0.05.
Conclusion: Insulin like growth factor 1 level is not a reliable indicator of growth hormone deficiency and lacks specificity.
It can support the diagnosis of growth hormone deficiency, but growth hormone stimulation test is still the gold standard test in highly suspected cases of growth hormone deficiency even with normal level of Insulin like growth factor 1.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alawinah, Husayn& Khalidi, Umar& Maita, Jamal& Fugaha, Nifin& Atum, Raid& Shatnawi, Muhammad. 2015. Insulin like growth factor 1 as an indicator of growth hormone deficiency. Journal of the Royal Medical Services،Vol. 22, no. 2, pp.13-17.
https://search.emarefa.net/detail/BIM-587699
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maita, Jamal…[et al.]. Insulin like growth factor 1 as an indicator of growth hormone deficiency. Journal of the Royal Medical Services Vol. 22, no. 2 (Jun. 2015), pp.13-17.
https://search.emarefa.net/detail/BIM-587699
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alawinah, Husayn& Khalidi, Umar& Maita, Jamal& Fugaha, Nifin& Atum, Raid& Shatnawi, Muhammad. Insulin like growth factor 1 as an indicator of growth hormone deficiency. Journal of the Royal Medical Services. 2015. Vol. 22, no. 2, pp.13-17.
https://search.emarefa.net/detail/BIM-587699
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 16-17
رقم السجل
BIM-587699
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر