Effect of insulin glargine on glycemic control in adolescents with type 1-diabetes
المؤلفون المشاركون
Hassan, Muna Muhammad
Hind, Sulayman M.
Hanan, Najib M.
Maha, Amin M.
المصدر
Egyptian Pediatric Association Gazette
العدد
المجلد 63، العدد 2 (30 يونيو/حزيران 2015)، ص ص. 35-38، 4ص.
الناشر
تاريخ النشر
2015-06-30
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Adolescence is a transitional phase characterized by multiple physiological and psychosocial factors that make glycemic control more difficult, and often results in hyperglycemia and/or hypoglycemia-related emergencies, and increases the risk of chronic complications.
Insulin analogs were introduced with the aim of overcoming such difficulties.
Objective: To study the role of long acting insulin analog (insulin glargine) in glycemic control of adolescents with poorly controlled type 1 diabetes who suffer from frequent hypoglycemic attacks and marked glucose variability, and to compare its effectiveness and cost versus intermediate acting insulin (NPH) in a country with limited resources like Egypt.
Subject and method: A non-randomized open label treat to target trial that included twenty-nine adolescents (10–18 years), with T1DM.
They were on MDI regimen.
All had unsatisfactory glycemic control with frequent hypoglycemia and/or recurrent glucose excursions.
All were shifted from twice daily NPH to single bedtime injection of insulin glargine (Lantus), and followed up for a minimum period of 6 months.
Results: Switching to insulin glargine was associated with a statistically significant reduction in attacks of hypoglycemia and DKA (p< 0.001), but with insignificant reduction in HbA1c (p= 0.9).
BMI showed a significant increase (p=0.004), as well as the cost of basal insulin as glargine compared to NPH.
Conclusion: The present study encourages the use of insulin glargine in the presence of significant hypoglycemia and glucose variability, with close monitoring of diet and weight.
Cost effectiveness and effect on HbA1c and quality of life need further longitudinal studies with larger numbers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hassan, Muna Muhammad& Maha, Amin M.& Hind, Sulayman M.& Hanan, Najib M.. 2015. Effect of insulin glargine on glycemic control in adolescents with type 1-diabetes. Egyptian Pediatric Association Gazette،Vol. 63, no. 2, pp.35-38.
https://search.emarefa.net/detail/BIM-592011
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hassan, Muna Muhammad…[et al.]. Effect of insulin glargine on glycemic control in adolescents with type 1-diabetes. Egyptian Pediatric Association Gazette Vol. 63, no. 2 (Jun. 2015), pp.35-38.
https://search.emarefa.net/detail/BIM-592011
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hassan, Muna Muhammad& Maha, Amin M.& Hind, Sulayman M.& Hanan, Najib M.. Effect of insulin glargine on glycemic control in adolescents with type 1-diabetes. Egyptian Pediatric Association Gazette. 2015. Vol. 63, no. 2, pp.35-38.
https://search.emarefa.net/detail/BIM-592011
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 37-38
رقم السجل
BIM-592011
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر