![](/images/graphics-bg.png)
Relationship between serum hepcidin and ferritin levels in patients with thalassemia major and intermedia in Southern Iran
المؤلفون المشاركون
Esmaeilzadeh, Masoomeh
Hunar, Nasir
al-Husni, Fatimah
Dehbozorgian, Javad
Ridaih, Narjis
Abd Allahi, Maryam
Burdistani, Mardiah
Safai, Sanaz
Karimi, Mahran
Haghpanah, Sezaneh
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 17، العدد 7 (31 يوليو/تموز 2015)، ص ص. 1-5، 5ص.
الناشر
تاريخ النشر
2015-07-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Hepcidin is a key regulator of iron absorption in humans.
It is mainly affected by hypoxia and iron stores.
Objectives : The current study aimed to determine the correlation between serum hepcidin and ferritin levels in patients with Thalassemia Major (TM) and Thalassemia Intermedia (TI).
Patients and Methods : The current cross-sectional study investigated 88 randomly selected patients with Thalassemia, 48 TM and 40 TI, registered at the Thalassemia Clinic of Shiraz University of Medical Sciences, a referral center for Thalassemia in Southern Iran in 2013.
All patients with TI were receiving Hydroxyurea (HU) 10 - 15 mg/kg/day for at least 10 years.
The serum hepcidin, ferritin levels, hemoglobin (Hb) and nucleated Red Blood Cell (RBC) of the two groups were measured.
Results : No statistically significant correlation was observed between serum hepcidin and ferritin levels in any of the two groups of patients with TM (rs = 0.02, P = 0.892) or TI (rs = 0.055, P = 0.734).
The median Interquartile Range (IQR) for serum hepcidin and ferritin levels were significantly higher in TM compared to TI group, (hepcidin: 87.6 (43.9) vs.
51.8 (23.4), P < 0.001; ferritin : 2208 (3761) vs.
465 (632), P < 0.001).
Conclusions : There was insignificant correlation between serum hepcidin and ferritin levels in the two groups of patients with TM and TI.
It seems that regulation of hepcidin in patients with Thalassemia is more affected by erythropoeitic activity than iron stores.
Also, hepcidin levels were significantly higher in patients with TM than TI, possibly due to higher erythropoeitic activity in TI.
In TI, it seems that low dose HU increases Hb levels and leads to transfusion-independence, but it is not high enough to suppress bone marrow activity and ineffective erythropoiesis.
Consequently, serum hepcidin level decreases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Haghpanah, Sezaneh& Esmaeilzadeh, Masoomeh& Hunar, Nasir& al-Husni, Fatimah& Dehbozorgian, Javad& Abd Allahi, Maryam…[et al.]. 2015. Relationship between serum hepcidin and ferritin levels in patients with thalassemia major and intermedia in Southern Iran. Iranian Red Crescent Medical Journal،Vol. 17, no. 7, pp.1-5.
https://search.emarefa.net/detail/BIM-593519
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Haghpanah, Sezaneh…[et al.]. Relationship between serum hepcidin and ferritin levels in patients with thalassemia major and intermedia in Southern Iran. Iranian Red Crescent Medical Journal Vol. 17, no. 7 (Jul. 2015), pp.1-5.
https://search.emarefa.net/detail/BIM-593519
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Haghpanah, Sezaneh& Esmaeilzadeh, Masoomeh& Hunar, Nasir& al-Husni, Fatimah& Dehbozorgian, Javad& Abd Allahi, Maryam…[et al.]. Relationship between serum hepcidin and ferritin levels in patients with thalassemia major and intermedia in Southern Iran. Iranian Red Crescent Medical Journal. 2015. Vol. 17, no. 7, pp.1-5.
https://search.emarefa.net/detail/BIM-593519
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 4-5
رقم السجل
BIM-593519
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)