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Caloric restriction and formalin-induced inflammation : an experimental study in rat model
المؤلفون المشاركون
Nozad, Aisan
Safari, Mir Bahram
Sabwry, Ihsan
Drafshpwr, Layla
Mughadam, Parwaniah Muhsini
Ghaffari, Farzanah
Nasiri, Muhsin
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 17، العدد 7 (31 يوليو/تموز 2015)، ص ص. 1-6، 6ص.
الناشر
تاريخ النشر
2015-07-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Acute and chronic inflammations are difficult to control.
Using chemical anti-inflammatory medications along with their complications considerably limit their use.
According to Traditional Iranian Medicine (TIM), there is an important relation between inflammation and Imtila (food and blood accumulation in the body); food reduction or its more modern equivalent Caloric Restriction (CR) may act against both Imtila and inflammation.
Objectives : This experimental study aimed to investigate the effect of 30% reduction in daily calorie intake on inflammation in rats.
Materials and Methods : A total of 18 male rats (Rattus rattus) weighing 220 to 270 g were obtained.
Then, the inflammation was induced by injecting formalin in their paws.
Next, the rats were randomized by generating random numbers into two equal groups (9 + 9) putting on either normal diet (controls) or a similar diet with 30% reduction of calorie (cases).
Paw volume changes were recorded twice per day by one observer in both groups using a standard plethysmometer for 8 consecutive days.
Serum C-reactive protein (CRP), Erythrocyte Sedimentation Rate (ESR), complete blood count (erythrocyte, platelet, and white blood cell) and hemoglobin were compared between the groups.
Results : Decline of both body weight and paw volume was significantly more prominent in the case than in the control rats within the study period (P < 0.001 and < 0.001, respectively).
Paw volume decrease was more prominent after day 3.
On day 8, serum CRP-positive (1 or 2 +) rats were more frequent in ad libitum fed group comparing with those received CR (33.3% vs.
11.1%).
This difference, however, was insignificant (P = 0.58).
At the same time, mean ESR was significantly higher in the control rats comparing with that in the case group (29.00 ± 2.89 h vs.
14.00 ± 1.55 h; P = 0.001).
Other serum parameters were not significantly different between the two groups at endpoint.
Conclusions : Rats fed with a 30% calorie-restricted diet in comparison with to ad libitum fed controls for 8 days had significantly more prominent regression of inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nozad, Aisan& Safari, Mir Bahram& Sabwry, Ihsan& Drafshpwr, Layla& Mughadam, Parwaniah Muhsini& Ghaffari, Farzanah…[et al.]. 2015. Caloric restriction and formalin-induced inflammation : an experimental study in rat model. Iranian Red Crescent Medical Journal،Vol. 17, no. 7, pp.1-6.
https://search.emarefa.net/detail/BIM-593832
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nozad, Aisan…[et al.]. Caloric restriction and formalin-induced inflammation : an experimental study in rat model. Iranian Red Crescent Medical Journal Vol. 17, no. 7 (Jul. 2015), pp.1-6.
https://search.emarefa.net/detail/BIM-593832
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nozad, Aisan& Safari, Mir Bahram& Sabwry, Ihsan& Drafshpwr, Layla& Mughadam, Parwaniah Muhsini& Ghaffari, Farzanah…[et al.]. Caloric restriction and formalin-induced inflammation : an experimental study in rat model. Iranian Red Crescent Medical Journal. 2015. Vol. 17, no. 7, pp.1-6.
https://search.emarefa.net/detail/BIM-593832
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 5-6
رقم السجل
BIM-593832
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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