Association of glutathione s-transferase (GSTM1, T1) gene polymorphisms with type 2 diabetes mellitus (T2DM) in the Iraqi Patients
المؤلفون المشاركون
Rashid, Maarib Nazih
Mahmud, Asil Shakir
Hasan, Usamah Muhammad
المصدر
Iraqi Journal of Biotechnology
العدد
المجلد 14، العدد 1 (30 يونيو/حزيران 2015)، ص ص. 70-76، 7ص.
الناشر
جامعة بغداد معهد الهندسة الوراثية و التقنيات الإحيائية للدراسات العليا
تاريخ النشر
2015-06-30
دولة النشر
العراق
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص AR
Diabetes mellitus is associated with an increased production of reactive oxygen species (ROS) and a reduction in antioxidant defense.
The oxidative stress becomes evident as a result of accumulation of ROS in conditions of inflammation and Type 2 diabetes mellitus (T2DM).
The genes involved in redox balance, which determines the susceptibility to T2DM remain unclear.
In humans, the glutathione S-transferase (GST) family comprises several classes of GST isozymes, the polymorphic variants of GSTM1, T1 genes result in decreased or loss of enzyme activity.
Aims: The present study evaluated the effect of genetic polymorphisms of the GST gene family on the risk of developing T2DM in the Iraqi patients.
GSTM1, T1 polymorphisms were genotyped in 25 T2DM patients and 25 healthy controls from Iraq to analyze their association with T2DM susceptibility.
Materials and Methods: Analysis of GSTM1 and GSTT1 gene polymorphisms was performed by multiplex polymerase chain reaction (PCR) .There was significant association in the GSTM1 gene polymorphism and Type-2 Diabetes Mellitus (P<0.05).
Moreover, significant relationship was found between the polymorphism of GSTT1 genes and higher risk of Type-2 Diabetes Mellitus among Iraqi subjects (P<0.05).
الملخص EN
Diabetes mellitus is associated with an increased production of reactive oxygen species (ROS) and a reduction in antioxidant defense.
The oxidative stress becomes evident as a result of accumulation of ROS in conditions of inflammation and Type 2 diabetes mellitus (T2DM).
The genes involved in redox balance, which determines the susceptibility to T2DM remain unclear.
In humans, the glutathione S-transferase (GST) family comprises several classes of GST isozymes, the polymorphic variants of GSTM1, T1 genes result in decreased or loss of enzyme activity.
Aims: The present study evaluated the effect of genetic polymorphisms of the GST gene family on the risk of developing T2DM in the Iraqi patients.
GSTM1, T1 polymorphisms were genotyped in 25 T2DM patients and 25 healthy controls from Iraq to analyze their association with T2DM susceptibility.
Materials and Methods: Analysis of GSTM1 and GSTT1 gene polymorphisms was performed by multiplex polymerase chain reaction (PCR) .There was significant association in the GSTM1 gene polymorphism and Type-2 Diabetes Mellitus (P<0.05).
Moreover, significant relationship was found between the polymorphism of GSTT1 genes and higher risk of Type-2 Diabetes Mellitus among Iraqi subjects (P < 0.05).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rashid, Maarib Nazih& Hasan, Usamah Muhammad& Mahmud, Asil Shakir. 2015. Association of glutathione s-transferase (GSTM1, T1) gene polymorphisms with type 2 diabetes mellitus (T2DM) in the Iraqi Patients. Iraqi Journal of Biotechnology،Vol. 14, no. 1, pp.70-76.
https://search.emarefa.net/detail/BIM-596145
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hasan, Usamah Muhammad…[et al.]. Association of glutathione s-transferase (GSTM1, T1) gene polymorphisms with type 2 diabetes mellitus (T2DM) in the Iraqi Patients. Iraqi Journal of Biotechnology Vol. 14, no. 1 (2015), pp.70-76.
https://search.emarefa.net/detail/BIM-596145
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rashid, Maarib Nazih& Hasan, Usamah Muhammad& Mahmud, Asil Shakir. Association of glutathione s-transferase (GSTM1, T1) gene polymorphisms with type 2 diabetes mellitus (T2DM) in the Iraqi Patients. Iraqi Journal of Biotechnology. 2015. Vol. 14, no. 1, pp.70-76.
https://search.emarefa.net/detail/BIM-596145
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 75-76
رقم السجل
BIM-596145
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر