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Impact of body mass index on clinic-pathological parameters and outcome in patients with metastatic prostate cancer
المؤلفون المشاركون
al-Tanni, Hani
al-Saifi, Amr M.
Ghanim, Hafiz M.
Muhammad, Amr Allah A.
al-Zahrani, Abd Allah S.
al-Shintinawi, Ayman
Faruq, Miyan U.
al-Khatib, Hani M.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 27، العدد 3 (30 سبتمبر/أيلول 2015)، ص ص. 155-159، 5ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2015-09-30
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: This study evaluates the correlation between body mass index (BMI) and clinicopathological parameters of metastatic prostate cancer (MPC) and its impact on survival.
Method: During the study period, 71 MPC patients were eligible.
Patients with BMI < 25.0 kg/m2 were categorized as level I and patients with BMI P 25.0 kg/m2 were categorized as level II.
Demographic features and survival rates were evaluated by the Kaplan–Meier method and Cox proportional models.
Results: 31 patients belonged to level I while the rest belonged to level II with insignificant higher median follow-up duration in level II; p= 0.5.
In terms of age, metastasis, serum level of albumin, prostatic specific antigen, alkaline phosphatase (AKP) and Gleason score, there was no significant difference between the two levels.
The cumulative survival probability in the 12th, 24th and 36th month in level I vs; level II was; 86.7%, 68.7%, 64.1% vs; 74.4%, 67.7%, 55.1%, respectively with 7 patients dead in level I compared to 14 patients dead in level II denoting a higher PC-specific death rate in the level II group.
In univariate and multivariate analysis, poor prognosis was associated with increasing AKP (HR = 1.0005, 95% CI, p=0.03; HR= 1.001, 95% CI, p= 0.03) respectively, while better prognosis was associated with no visceral metastasis (HR =0.09, 95% CI, p =0.000; HR= 0.04, 95% CI, p= 0.000) and increasing albumin levels (HR = 0.17, 95% CI, p=0.000;HR= 0.15, 95% CI, p= 0.000) respectively.
In multivariate analysis only, patients belonging to level I were associated with better prognosis (HR = 0.17, 95% CI, p= 0.02).
Conclusion: BMI is dependent on prognostic factors in patients with MPC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhammad, Amr Allah A.& al-Tanni, Hani& Ghanim, Hafiz M.& Faruq, Miyan U.& al-Saifi, Amr M.& al-Zahrani, Abd Allah S.…[et al.]. 2015. Impact of body mass index on clinic-pathological parameters and outcome in patients with metastatic prostate cancer. Journal of the Egyptian National Cancer Institute،Vol. 27, no. 3, pp.155-159.
https://search.emarefa.net/detail/BIM-600673
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhammad, Amr Allah A.…[et al.]. Impact of body mass index on clinic-pathological parameters and outcome in patients with metastatic prostate cancer. Journal of the Egyptian National Cancer Institute Vol. 27, no. 3 (Sep. 2015), pp.155-159.
https://search.emarefa.net/detail/BIM-600673
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhammad, Amr Allah A.& al-Tanni, Hani& Ghanim, Hafiz M.& Faruq, Miyan U.& al-Saifi, Amr M.& al-Zahrani, Abd Allah S.…[et al.]. Impact of body mass index on clinic-pathological parameters and outcome in patients with metastatic prostate cancer. Journal of the Egyptian National Cancer Institute. 2015. Vol. 27, no. 3, pp.155-159.
https://search.emarefa.net/detail/BIM-600673
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 158-159
رقم السجل
BIM-600673
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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