Integrin-Linked Kinase, snail and multidrug resistance protein 1 : three concordant players in the progression of non-small cell lung cancer
المؤلفون المشاركون
Abd al-Ghani, Manal I.
Nazmi, Mayadah H.
Abd al-Rahim, Daliyah M.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 27، العدد 3 (30 سبتمبر/أيلول 2015)، ص ص. 129-137، 9ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2015-09-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Integrin Linked Kinase (ILK), Snail and Multidrug Resistance Protein 1 (MRP1) have been implicated in several cancers; however, their roles in non-small cell lung cancer (NSCLC) remain to be elucidated.
Aim: Investigation of their expression in NSCLC tissue.
Relationships among these proteins and their association with clinicopathological parameters were studied.
Materials and methods: ILK, Snail and MRP1 expression were immunohistochemically assessed in 97 tumor tissues.
Furthermore, western blot analysis for ILK, Snail and MRP1 in 6 cases of NSCLC was also performed.
Results: ILK overexpression, positive Snail and MRP1 expression were found in 46.4%, 36.1% and 49.5% of tumors respectively.
ILK expression was significantly correlated with tumor grade (p= 0.013), lymph node (LN) metastases (p= 0.001) and stage (p=0.001).
Positive Snail and MRP1 expression were significantly associated with LN metastasis (p= 0.004 and 0.022, respectively) and advanced stage disease (p= 0.018 and 0.024, respectively).
MRP1 expression was significantly higher among adenocarcinoma cases compared to other types (p= 0.001).
ILK over-expression was significantly associated with up-regulation of Snail and MRP1 (p< 0.001 both).
Significant association was also, found between Snail and MRP1 expression (p= 0.005).
Moreover, the co-expression of two markers or more was significantly associated with less differentiation (p= 0.011), advanced tumor status (p=0.030), LN metastasis (p< 0.001) and advanced stage (p <0.001) disease.
Western blot analysis validated immunohistochemical findings.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Rahim, Daliyah M.& Abd al-Ghani, Manal I.& Nazmi, Mayadah H.. 2015. Integrin-Linked Kinase, snail and multidrug resistance protein 1 : three concordant players in the progression of non-small cell lung cancer. Journal of the Egyptian National Cancer Institute،Vol. 27, no. 3, pp.129-137.
https://search.emarefa.net/detail/BIM-600733
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Rahim, Daliyah M.…[et al.]. Integrin-Linked Kinase, snail and multidrug resistance protein 1 : three concordant players in the progression of non-small cell lung cancer. Journal of the Egyptian National Cancer Institute Vol. 27, no. 3 (Sep. 2015), pp.129-137.
https://search.emarefa.net/detail/BIM-600733
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Rahim, Daliyah M.& Abd al-Ghani, Manal I.& Nazmi, Mayadah H.. Integrin-Linked Kinase, snail and multidrug resistance protein 1 : three concordant players in the progression of non-small cell lung cancer. Journal of the Egyptian National Cancer Institute. 2015. Vol. 27, no. 3, pp.129-137.
https://search.emarefa.net/detail/BIM-600733
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 136-137
رقم السجل
BIM-600733
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر