Does intrauterine insemination in Saudi female cause production of antisperm antibodies ?

الملخص EN

Objective : To determine the possibility of inducing antisperm antibodies in patients undergoing intrauterine insemination with motile sperms from the husband.

Design : Clinico-immunological prospective study.

Setting : King Abdulaziz University Hospital.

Subjects : Fifty patients undergoing Intrauterine Insemination (IUI), were tested for developing antisperm antibodies using agglutination test, complement mediated immobilization test, and immunoglobin specific indirect immunobead assay.

Main outcome measures: Incidence and type of antisperms antibodies.

Results : Forty seven out of 50 patient remained negative for antisperm antibodies after 2- 6 cycles of IUI.

Detection of antisperm antibodies after IUI was evident in 3 patients