Inhibited thyroid function, impaired lipid metabolism and increased tissue oxidative stress in rats native to high altitude
المؤلفون المشاركون
al-Daghiri, Nasir
Khalil, Muhmmad A.
Faris, Nur al-Din M.
al-Khatib, Mahmud A.
al-Hashim, Fahd H.
Shatur, Abd Allah S.
المصدر
العدد
المجلد 34، العدد 2 (30 يونيو/حزيران 2012)، ص ص. 1-10، 10ص.
الناشر
تاريخ النشر
2012-06-30
دولة النشر
البحرين
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Objective : To evaluate the effect of high altitude on markers of thyroid function, serum lipid profile and tissues oxidative stress in male Wistar rats native tohigh altitude (HA) with male rats native to low altitude (LA).
Design : Randomized experimental animal study.
Setting : Physiology laboratory, Medical School of King Khalid University.
Method : Male rats agedsix months, weighing 250 gm were bred and maintained at low altitude (LA, 600 m above sea level, n = 6) or high altitude (HA, 2800 m, n = 6), under the same laboratory conditions and fed the same diet.
Blood samples were obtained for thyroid hormones and lipid profile analysis.
Livers, kidneys, lungs and testes were collected and used for determination levels of thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), Superoxide Dismutase (SOD) and Catalase Activity (CAT).
Result : HA rats had significantly (P < 0.05) lower serum T3 (17.14 %), T4 (13.75 %), TSH (39.29 %) and total cholesterol (15.84 %) and LDL (60.90 %).
There were no significant differences in TAG or HDL.
All tissues from HA rats showed significant decreases in SOD and CAT activities compared to LA rats.
These rats showed significantly higher oxidative stress in the lungs and the liver, but lower oxidative stress in the kidney and no difference in the testes.
Conclusion : Living at high altitude environment results in impaired thyroid function and lipid metabolism and causes increased tissue oxidative stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Hashim, Fahd H.& Shatur, Abd Allah S.& al-Daghiri, Nasir& Khalil, Muhmmad A.& Faris, Nur al-Din M.& al-Khatib, Mahmud A.. 2012. Inhibited thyroid function, impaired lipid metabolism and increased tissue oxidative stress in rats native to high altitude. Bahrain Medical Bulletin،Vol. 34, no. 2, pp.1-10.
https://search.emarefa.net/detail/BIM-602724
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Hashim, Fahd H.…[et al.]. Inhibited thyroid function, impaired lipid metabolism and increased tissue oxidative stress in rats native to high altitude. Bahrain Medical Bulletin Vol. 34, no. 2 (Jun. 2012), pp.1-10.
https://search.emarefa.net/detail/BIM-602724
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Hashim, Fahd H.& Shatur, Abd Allah S.& al-Daghiri, Nasir& Khalil, Muhmmad A.& Faris, Nur al-Din M.& al-Khatib, Mahmud A.. Inhibited thyroid function, impaired lipid metabolism and increased tissue oxidative stress in rats native to high altitude. Bahrain Medical Bulletin. 2012. Vol. 34, no. 2, pp.1-10.
https://search.emarefa.net/detail/BIM-602724
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 9-10
رقم السجل
BIM-602724
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر