Cystinuria in Arab countries
المؤلفون المشاركون
Abbas, Bassim
al-Hirmi, Badriyah
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 14، العدد 3 (30 يونيو/حزيران 2003)، ص ص. 358-366، 9ص.
الناشر
تاريخ النشر
2003-06-30
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Recent advances in molecular biology have provided new insights into the pathophysiology and genetics of cystinuria.
It is expected that future development will be based on molecular and gene therapy.
Until then, the therapy in cystinuric patients remains a difficult task and the goal should be the prevention of recurrences.
This can be achieved by full compliance with medical regimens that result in significantly reduced urinary cystine excretion and good long-term prognosis in most patients.
Such measures include urinary alkalinization with potassium citrate, modest reduction of dietary sodium and maintenance of a daily urinary volume of about three liters to prevent stone recurrence in adult cystinuric patients.
The use of life-long pharmacological agents with disulfide chelators should be reserved for patients who fail the general conservative therapy.
Invasive surgery should be used only minimally so as to preserve renal anatomy and function.
However, repeated episodes of obstructive uropathy, frequently complicated by infection may eventually result in the need for nephrectomy, and are significantly associated with development of chronic renal failure.
In the Arab World we lack properly designed epidemiological studies on renal stone-disease in general, and the cystine stones in particular.
We recommend a multi-center study to determine the incidence of the disease and a molecular genetic analysis of cystinuric patients and their relatives, to determine the different mutations in our population and the types of the disease both the homozygotes and the heterozygotes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Hirmi, Badriyah& Abbas, Bassim. 2003. Cystinuria in Arab countries. Saudi Journal of Kidney Diseases and Transplantation،Vol. 14, no. 3, pp.358-366.
https://search.emarefa.net/detail/BIM-60423
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Hirmi, Badriyah& Abbas, Bassim. Cystinuria in Arab countries. Saudi Journal of Kidney Diseases and Transplantation Vol. 14, no. 3 (Aug. 2003), pp.358-366.
https://search.emarefa.net/detail/BIM-60423
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Hirmi, Badriyah& Abbas, Bassim. Cystinuria in Arab countries. Saudi Journal of Kidney Diseases and Transplantation. 2003. Vol. 14, no. 3, pp.358-366.
https://search.emarefa.net/detail/BIM-60423
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 364-366
رقم السجل
BIM-60423
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر