Synthesis and characterization of some new compounds of imide moiety and their antibacterial evaluating

الملخص EN

In the present study, a series of novel phthalimide derivatives are synthesized because of its potent antibacterial activity.

structurally modified phthalimide derivatives are prepared through condensation of 4-(1,3-dioxoisoindolin-2-yl) benzoyl chloride with corresponding furan-2-carbohydrazide , 5-(isopropylthio)-1,3,4-thiadiazole -2-amine,5-(4-chloro phenyl)-1,3,4-thiadiazole-2-amine and 4,7-dichlorobenzo[d]thiazol-2-amine with variable yields.

structures of the prepared compounds were confirmed by spectroscopic methods including FT-IR and 1H-NMR.

Finally antibacterial activity of some of the prepared new cyclic imides are evaluated against two types of bacterial Eschericha-coli and Staphylococcus aureus and the results show that the most of the tested imides posses good biological activity against these organisms.