Hormones in premenstrual syndrome

الملخص EN

Twenty patients with Premenstual Syndrome (PMS) and ei؛؛hte،؛n control subjects were studied to determine whether estrogen, progesterone, or prolac-tin hormone levels are associated with PMS.

Blood samples were collected 7-1(، days before the menstrual cycle.

There was no significant differences between the two groups (P > 0.1) indicating the endocrine effect during the luteal phase which do not directly generate the symptoms of PMS.

Since Frank introduced the term premenstrual ten-sion for a group of symptoms occurring during the pre-menstruum, several theories have been postulated for the pathophysiology of this syndrome'“*.

The association between ovarian function and PMS had led many investigators to speculate that an imbalance in the production of estrogen and progesterone may be the underlying factor that precipitates PMS5.

Elevated prolactin decreases progesterone secretion by altering gonadotrophin secretion and directly interfering with ovar-ian steroidogenesis^.

This study is a trial to determine whether changes in the level of estrogen, progesterone, or prolactin are as-sociated with symptoms of PMS in a group of Saudi Women.