Cancer ameliorating potential of phyllanthus amarus : in vivo and in vitro studies against aflatoxin B1 toxicity
المؤلفون المشاركون
Banu, Sultanah
Anwar, Shafat
Ahmad, M. Sultan
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 16، العدد 4 (31 أكتوبر/تشرين الأول 2015)، ص ص. 343-353، 11ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2015-10-31
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Green medicine is safe and more dependable than the costly synthetic drugs.
Phyllanthus amarus is one of them that have enormous medicinal potential.
Aim : In these experiments, we have evaluated the anticlastogenic, antigenotoxic and antimutagenic potential of P.
amarus extract.
Subject and methods: In this experiment we have used in vitro human lymphocyte culture and in vivo bone marrow cells of Albino mice.
The parameters used were chromosomal aberrations (CA), sister chromatid exchanges (SCEs) and cell growth kinetics (RI) both in the presence as well as in the absence of S9-mix (for in vitro study) and total aberrant cells and the frequencies of aberrations per cell (for in vivo study).
Alcoholic extracts of P.
amarus was obtained by Soxhlet extractor.
Results : Extracts of P.
amarus significantly reduces chromosomal aberrations from 34.49%, 68.47% and 78.65% at 24 h, 48 h, and 72 h produced by Aflatoxin B1 (AFB1) to 19.32%, 48.00% and 51.88% level.
Similarly sister chromatid exchanges were reduced from 17.76 ± 1.50 (SE) to 09.76 ± 1.20 (SE) at 48 h of treatment, whereas replication index was enhanced in vitro for each concentration and duration of treatment.
It also significantly reduced the number of aberrant cells and frequency of aberrations per cell in vivo.
Conclusion: Ameliorating potential of P.
amarus was dose and duration dependant.
These extracts significantly reduced the mutagenicity and genotoxicity that were produced due to AFB1 treatment both in vitro and in vivo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahmad, M. Sultan& Banu, Sultanah& Anwar, Shafat. 2015. Cancer ameliorating potential of phyllanthus amarus : in vivo and in vitro studies against aflatoxin B1 toxicity. The Egyptian Journal of Medical Human Genetics،Vol. 16, no. 4, pp.343-353.
https://search.emarefa.net/detail/BIM-607916
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahmad, M. Sultan…[et al.]. Cancer ameliorating potential of phyllanthus amarus : in vivo and in vitro studies against aflatoxin B1 toxicity. The Egyptian Journal of Medical Human Genetics Vol. 16, no. 4 (2015), pp.343-353.
https://search.emarefa.net/detail/BIM-607916
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahmad, M. Sultan& Banu, Sultanah& Anwar, Shafat. Cancer ameliorating potential of phyllanthus amarus : in vivo and in vitro studies against aflatoxin B1 toxicity. The Egyptian Journal of Medical Human Genetics. 2015. Vol. 16, no. 4, pp.343-353.
https://search.emarefa.net/detail/BIM-607916
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 353
رقم السجل
BIM-607916
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر