Metabolic abnormalities in young Egyptian Women with polycystic ovary syndrome and their relation to ADIPOQ gene variants and body fat phenotype
المؤلفون المشاركون
Zaki, Mushirah
Ismail, Sumayyah
Abd al-Rauf, Hiyam
Hulwah, Iman
Hassan, Najla
Kamal, Sana
Yusuf, Wala
Izzat, Wafa
al-Husari, Yasir A.
Salih, Umniyah M.
Ismail, Samirah
Baybars, Mamduh
Azmi, Usamah
al-Jamal, Muna
al-Basyuni, Halah T.
Muhammad, Nadiyah A.
Shakir, Muhammad
Khulusi, Shams
Yunus, Iman
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 16، العدد 4 (31 أكتوبر/تشرين الأول 2015)، ص ص. 367-374، 8ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2015-10-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Polycystic ovary syndrome (PCOS) is the most common endocrine disorder.
It is associated with high prevalence of metabolic risk factors, but little is known about the prevalence of metabolic syndrome (MS) and its components among Egyptian PCOS women.
The objective of the study was to determine the metabolic abnormalities among young Egyptian women with PCOS and evaluate their relation with adiponectin gene (ADIPOQ) variants and body fat adiposity pattern.
Materials and methods : The present study included 80 PCOS women and 80 healthy women with similar age and body mass index.
All participants underwent clinical, anthropometric, biochemical, ultrasonographic and adiponectin (ADIPOQ) gene 11391G > A (rs17300539) examinations.
Insulin resistance was assessed by the Homeostatic model assessment for insulin resistance (HOMA-IR).
Results : MS was identified in 22.5% of PCOS women.
The most prevalent MS components in PCOS women were central obesity, decreased high-density lipoprotein cholesterol (HDL-C), and increased triglycerides (TG), blood pressure (BP) and fasting glucose levels.
The study found association between ADIPOQ promoter variants 11391G>A and MS in PCOS women.
Moreover, multivariate logistic regression analysis showed association between abdominal fat accumulation and IR in PCOS.
Conclusion : The prevalence of MS was significantly higher in PCOS women than controls, and central obesity and hypertension are risk factors for insulin resistance.
Moreover, obesity plays a key role in the development of PCOS and ADIPOQ 11391G>A gene variants showed association with MS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zaki, Mushirah& Khulusi, Shams& Ismail, Sumayyah& Abd al-Rauf, Hiyam& Hulwah, Iman& Hassan, Najla…[et al.]. 2015. Metabolic abnormalities in young Egyptian Women with polycystic ovary syndrome and their relation to ADIPOQ gene variants and body fat phenotype. The Egyptian Journal of Medical Human Genetics،Vol. 16, no. 4, pp.367-374.
https://search.emarefa.net/detail/BIM-608167
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zaki, Mushirah…[et al.]. Metabolic abnormalities in young Egyptian Women with polycystic ovary syndrome and their relation to ADIPOQ gene variants and body fat phenotype. The Egyptian Journal of Medical Human Genetics Vol. 16, no. 4 (2015), pp.367-374.
https://search.emarefa.net/detail/BIM-608167
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zaki, Mushirah& Khulusi, Shams& Ismail, Sumayyah& Abd al-Rauf, Hiyam& Hulwah, Iman& Hassan, Najla…[et al.]. Metabolic abnormalities in young Egyptian Women with polycystic ovary syndrome and their relation to ADIPOQ gene variants and body fat phenotype. The Egyptian Journal of Medical Human Genetics. 2015. Vol. 16, no. 4, pp.367-374.
https://search.emarefa.net/detail/BIM-608167
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 373-374
رقم السجل
BIM-608167
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر