Synthesis, characterization and antibacterial activity of cefalexin dervatives

الملخص EN

New series of Schiff bases 2(a-j) and corresponding beta-lactam derivatives 3(a-j) were synthesized from cefalexin (1) as starting material.

The compound (1) was reacted with different aldehydes and ketones to give Schiff bases derivatives 2(a-j).

The synthesized Schiff bases were cyclized by chloroacetyl chloride in the presence of triethylamine to form beta-lactam derivatives 3(a-j).

The compounds were characterized by deremination melting point, FT-IR and 1H NMR.

The beta-lactam derivatives were screened in vitro antibacterial against some bacterial species.