Familial aggregation for myopia and contributions of environmental and genetic factors
المؤلفون المشاركون
Fotouhi, A.
Holakouic, K.
Hashimi, H.
المصدر
Medical Journal of the Iranian Hospital
العدد
المجلد 6، العدد 1 (31 يوليو/تموز 2003)، ص ص. 52-56، 5ص.
الناشر
تاريخ النشر
2003-07-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : The etiology of myopia, the most common refractive error, is known to involve a host of genetic and environmental causes but the precise contribution of these factors and their interactions are yet to be defined.
The objective of this project is to examine familial relationships for myopia among siblings of myopic patients and the distributions of hereditary and environmental factors on it. Methods : In this study, 401(81.1%) siblings out of 490 invited sibling were participated from 162 families.
The participants aged 16 years and above, had myopia of at least 0.5 diopters in one or both eyes.
We performed visual examinations and interviews for data on the manifest refraction, age, sex, ethnic, height, education and the amount of near works.
Odds Ratios (OR) were used as a measure of familial aggregation and logistic regression with approach of second order Generalized Estimating Equations (GEE) was fitted to control possible of confounding factors. Results : Of the participants, 315 (78.6%) were myopic.
There is strong evidence for a familial aggregation, as the odds ratio for myopia among family members was 4.13 (95% CI=2.47-6.89, P < 0.001).
Among other variables, only sex and education showed a significant association with myopia; after adjustment for these factors, the familial -aggregation persisted with OR = 2.18 (95% CI = 1.67-2.84, P < 0.001).
Conclusion : There is an obvious familial aggregation for myopia, but the association is somewhat attenuated by adjusting for education and sex, and these confounding variables may in turn act through genetic or environmental mechanisms.
We conclude that both heredity and environment are at work in myopia and further studies are needed to confirm and quantify their respective effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fotouhi, A.& Holakouic, K.& Hashimi, H.. 2003. Familial aggregation for myopia and contributions of environmental and genetic factors. Medical Journal of the Iranian Hospital،Vol. 6, no. 1, pp.52-56.
https://search.emarefa.net/detail/BIM-61146
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Holakouic, K.…[et al.]. Familial aggregation for myopia and contributions of environmental and genetic factors. Medical Journal of the Iranian Hospital Vol. 6, no. 1 (Jul. 2003), pp.52-56.
https://search.emarefa.net/detail/BIM-61146
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fotouhi, A.& Holakouic, K.& Hashimi, H.. Familial aggregation for myopia and contributions of environmental and genetic factors. Medical Journal of the Iranian Hospital. 2003. Vol. 6, no. 1, pp.52-56.
https://search.emarefa.net/detail/BIM-61146
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 56
رقم السجل
BIM-61146
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر