The role of family history of neoplastic disorders in 100 patient s with primary brest cancer

الملخص EN

To find whether the family history of neoplasia is a risk factor for breast cancer (BC) in Iran, 100) patients with primary BC were studied.

The mean±SD of age of the patients was S0±l I years.

In 52% of them left and in 48% right breast was involved.

The most frequent pathologic classification was infiltrating ductal carcinoma (IDC).

Tumour size ranged between 0.4 to (> centimeters.

Sixty two percent of the subjects had axillary lymph node involvement, and 42% had family history of at least one neoplastic disorder.

excluding breast cancers in their pedigrees.

1 he total number of neoplasias was 108 in which lit" 27%, colon, uterus, and leukaemia, each 7% were among the more frequent cancers in the pedigrees, and among 2M cases with B( , 19 pedigrees had just one case of B( , The origin of neoplasia was more maternal, nith maternal/paternal ratio of 34/6, Comparative- study using HIM health) control subjects, revealed a strong association between a family history of am neoplasia and occurrence of breast cancer in family (crude OR-7.63 with P=0.0001 : in casts 42 out of 100 had family history of neoplasia versus 9 out of 100 in control?)}.

"Further studies needed to evaluate the rote of family history of neoplastic disorders for the risk of developing BC.