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Early detection of tubulo-interstitial kidney disease in children using highly discriminating sds-gel electrophoresis
المؤلفون المشاركون
al-Bashir, Amin
Mann, Helmut
Rohrmann, D.
Mertens, R.
Melzer, H.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 12، العدد 4 (31 أغسطس/آب 2001)، ص ص. 503-510، 8ص.
الناشر
تاريخ النشر
2001-08-31
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Tubulo-interstitial kidney disease is characterized by moderate proteinuria < 1 g / day of low molecular weight proteins in range of MW 10.000-50.000.
Even in the physiological proteinuria of < 150 mg / day, tubulo-interstitial kidney disease may exist.
Using optimized sodium dodecyl sulfate polyacrylamid gel electrophoresis (SDS-PAGE) according to the method of Melzer, even in proteinuria of less than 150 mg / day all relevant proteins for diagnosis of glomerular or tubulo-interstitial kidney disease can be detected.
This study evaluates the tubulo-interstitial kidney disease due to polychemotherapy for different types of cancer in 115 children and in 16 children with pyelo-ureteral junction obstruction.
Fifty-two and 63 children were followed up during and after chemotherapy, respectively.
During therapy, renal damage was recorded in 43 % of patients with leukemia, 56 % with nephroblastoma, and 79 % with other tumors.
Tubular protein patterns were seen up to three years after termination of chemotherapy (25 % in acute lymphoplastic leukemia, 35 % in nephroblastoma and 62 % in other tumors).
Patients with persistent complete tubular proteinuria or mixed glomerular / tubular proteinuria were found to have a high risk for irreversible renal failure.
Children with congenital pyelo-ureteral junction obstruction could also be classified according to SDS-PAGE protein patterns.
Patients without parenchymal lesions did not need surgery.
Most of those with pathologic findings in SDS-PAGE exhibited partial or complete remission after surgery.
The highly discriminating SDS-PAGE permits a rapid, sensitive, reproducible, and reliable analysis of urine proteins for diagnosis and follow-up of all kinds of congenital or acquired renal parenchymal kidney diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Bashir, Amin& Rohrmann, D.& Mertens, R.& Melzer, H.& Mann, Helmut. 2001. Early detection of tubulo-interstitial kidney disease in children using highly discriminating sds-gel electrophoresis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 12, no. 4, pp.503-510.
https://search.emarefa.net/detail/BIM-61883
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Bashir, Amin…[et al.]. Early detection of tubulo-interstitial kidney disease in children using highly discriminating sds-gel electrophoresis. Saudi Journal of Kidney Diseases and Transplantation Vol. 12, no. 4 (Dec. 2001), pp.503-510.
https://search.emarefa.net/detail/BIM-61883
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Bashir, Amin& Rohrmann, D.& Mertens, R.& Melzer, H.& Mann, Helmut. Early detection of tubulo-interstitial kidney disease in children using highly discriminating sds-gel electrophoresis. Saudi Journal of Kidney Diseases and Transplantation. 2001. Vol. 12, no. 4, pp.503-510.
https://search.emarefa.net/detail/BIM-61883
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 510
رقم السجل
BIM-61883
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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