Early detection of tubulo-interstitial kidney disease in children using highly discriminating sds-gel electrophoresis
المؤلفون المشاركون
al-Bashir, Amin
Mann, Helmut
Rohrmann, D.
Mertens, R.
Melzer, H.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 12، العدد 4 (31 أغسطس/آب 2001)، ص ص. 503-510، 8ص.
الناشر
تاريخ النشر
2001-08-31
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Tubulo-interstitial kidney disease is characterized by moderate proteinuria < 1 g / day of low molecular weight proteins in range of MW 10.000-50.000.
Even in the physiological proteinuria of < 150 mg / day, tubulo-interstitial kidney disease may exist.
Using optimized sodium dodecyl sulfate polyacrylamid gel electrophoresis (SDS-PAGE) according to the method of Melzer, even in proteinuria of less than 150 mg / day all relevant proteins for diagnosis of glomerular or tubulo-interstitial kidney disease can be detected.
This study evaluates the tubulo-interstitial kidney disease due to polychemotherapy for different types of cancer in 115 children and in 16 children with pyelo-ureteral junction obstruction.
Fifty-two and 63 children were followed up during and after chemotherapy, respectively.
During therapy, renal damage was recorded in 43 % of patients with leukemia, 56 % with nephroblastoma, and 79 % with other tumors.
Tubular protein patterns were seen up to three years after termination of chemotherapy (25 % in acute lymphoplastic leukemia, 35 % in nephroblastoma and 62 % in other tumors).
Patients with persistent complete tubular proteinuria or mixed glomerular / tubular proteinuria were found to have a high risk for irreversible renal failure.
Children with congenital pyelo-ureteral junction obstruction could also be classified according to SDS-PAGE protein patterns.
Patients without parenchymal lesions did not need surgery.
Most of those with pathologic findings in SDS-PAGE exhibited partial or complete remission after surgery.
The highly discriminating SDS-PAGE permits a rapid, sensitive, reproducible, and reliable analysis of urine proteins for diagnosis and follow-up of all kinds of congenital or acquired renal parenchymal kidney diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Bashir, Amin& Rohrmann, D.& Mertens, R.& Melzer, H.& Mann, Helmut. 2001. Early detection of tubulo-interstitial kidney disease in children using highly discriminating sds-gel electrophoresis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 12, no. 4, pp.503-510.
https://search.emarefa.net/detail/BIM-61883
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Bashir, Amin…[et al.]. Early detection of tubulo-interstitial kidney disease in children using highly discriminating sds-gel electrophoresis. Saudi Journal of Kidney Diseases and Transplantation Vol. 12, no. 4 (Dec. 2001), pp.503-510.
https://search.emarefa.net/detail/BIM-61883
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Bashir, Amin& Rohrmann, D.& Mertens, R.& Melzer, H.& Mann, Helmut. Early detection of tubulo-interstitial kidney disease in children using highly discriminating sds-gel electrophoresis. Saudi Journal of Kidney Diseases and Transplantation. 2001. Vol. 12, no. 4, pp.503-510.
https://search.emarefa.net/detail/BIM-61883
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 510
رقم السجل
BIM-61883
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر