Synthesis of spiro pyrrolidines from the addition of schiff bases to α-arylidene cyclohexanones

الملخص EN

A series of α-arylidene cyclohexanones (1-4) had been prepared via Claisen-Schmidt condensation, while other series of N-arylidene benzylamines (Schiff bases 5-10) had also been synthesized by equimolar addition.

The 1,3-anionic cycloaddition of Schiff bases to α-arylidene cyclohexanones under basic conditions afforded the corresponding spiro pyrrolidines (11-23).

The structures of the products are supported by valid spectral data and physical properties.

Theoretical data had been used to support the suggested mechanism.