Extrapituitary prolactin-1149 GT promoter polymorphism in some rheumatoid arthritis patients
المؤلف
المصدر
al-Kindy College Medical Journal
العدد
المجلد 11، العدد 1 (30 يونيو/حزيران 2015)، ص ص. 40-44، 5ص.
الناشر
تاريخ النشر
2015-06-30
دولة النشر
العراق
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Prolactin is a hormone, as well as a cytokine which is synthesized and secreted from the anterior pituitary gland and various extra pituitary sites including immune cells under control of a superdistal promoter that contains a single nucleotide polymorphism -1149 G/T.
Rheumatoid Arthritis has been associated with increased serum prolactin levels.
Objectives: To investigate the association of the extra pituitary -1149 G/T promoter polymorphism among Iraqi rheumatoid arthritis patients and prolactin levels.
Methods: We tested 73 patients with rheumatoid arthritis and 40 healthy individuals.
The DNA samples were genotyped using the Polymerase Chain Reaction-Restriction fragment Length Polymorphism method and the levels of prolactin serum were measured using Enzyme linked immunosorbent assay.
Results: The parameters rheumatoid factor, C-reactive protein, erythrocyte sedimentation rate and serum prolactin concentrations of rheumatoid arthritis patients were significantly increased compared with healthy controls.
The frequency of T allele and TT genotype was highest in control group compared with their frequency in rheumatoid arthritis patients, vice versa the G allele and GG genotype.
There is significant differences in prolactin levels in rheumatoid arthritis patients compared with healthy controls according to PRL-1149 G/T polymorphism.
In rheumatoid arthritis patients, carriers of the GG, GT genotypes had higher prolactin levels in comparison to TT genotype but did not show any significant difference.
Conclusions: There is a possible association between prolactin levels and rheumatoid arthritis.
We found correlation between rheumatoid arthritis and prolactin -1149 G/T polymorphism.
The prolactin -1149 G allele is a genetic marker for increased rheumatoid arthritis susceptibility in Iraqi population.
In addition, influence of prolactin -1149 G/T polymorphism on prolactin levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Azzawi, Adnan Fadil. 2015. Extrapituitary prolactin-1149 GT promoter polymorphism in some rheumatoid arthritis patients. al-Kindy College Medical Journal،Vol. 11, no. 1, pp.40-44.
https://search.emarefa.net/detail/BIM-624316
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Azzawi, Adnan Fadil. Extrapituitary prolactin-1149 GT promoter polymorphism in some rheumatoid arthritis patients. al-Kindy College Medical Journal Vol. 11, no. 1 (2015), pp.40-44.
https://search.emarefa.net/detail/BIM-624316
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Azzawi, Adnan Fadil. Extrapituitary prolactin-1149 GT promoter polymorphism in some rheumatoid arthritis patients. al-Kindy College Medical Journal. 2015. Vol. 11, no. 1, pp.40-44.
https://search.emarefa.net/detail/BIM-624316
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 43-44
رقم السجل
BIM-624316
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر