Determination of potential role of antioxidative status and circulating biochemical markers in the pathogenesis of ethambutol induced toxic optic neuropathy among diabetic and non-diabetic patients
المؤلفون المشاركون
Aziz, Khuram
Mahmud, Aminah
Zahir, Saymah
Shuja, Navid
Qadi, Mahmud Husayn
Karim, Sajjad
Malik, Arif
Kamal, Muhammad Amjad
Abd al-Mannan
Rasul, Mahmud
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 22، العدد 6 (30 نوفمبر/تشرين الثاني 2015)، ص ص. 739-743، 5ص.
الناشر
تاريخ النشر
2015-11-30
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
The present study was designed to explore the antioxidative status and circulating biochemical markers having a potential role in the pathogenesis of ethambutol (EMB) induced toxic optic neuropathy (TON) among diabetic and non-diabetic patients.
Fifty patients under complete therapy of EMB for tuberculosis were included in the present study.
Inclusion criteria for patients were to receive EMB everyday during treatment, a dose of 25 mg/kg for initial 2 months and 15 mg/kg during the rest of therapy period.
We conducted color vision and visual acuity test for all patients.
Fifteen out of fifty EMB induced TON patients, were found to be diabetic.
Color vision and visual acuity test results were evaluated for diabetic and non-diabetic as well as twenty age matched controls.
The results demonstrated a significant pattern of circulating biochemical markers between the studied groups.
Data regarding hematological (RBC, p value = 0.02; Hemoglobin, p value = 0.02), hepatic (total bilirubin, p value = 0.01), renal (urea, p value = 0.03; creatinine, p value = 0.007), lipid (total cholesterol, p value = 0.01; total triglycerides, p value = 0.03) and antioxidative (superoxide dismutase, p value = 0.005; glutathione, p value = 0.02; catalase, p value = 0.02) profile showed a highly significant difference among the studied groups specially patients with diabetes.
Malondialdehyde (MDA) level had gone significantly up in diabetic TON patients (p value = 0.02), in comparison to other antioxidants and vitamins (Vit).
Vit-A, E, B1, B12 and Zinc seem to be playing a major role in the pathogenesis of TON, specially Vit-E and B1 surpassed all the antioxidants as having highly significant inverse relationships with MDA (MDA vs Vit-E, r = 0.676** and MDA vs Vit-B1, r = 0.724** respectively).
We conclude that during the ethambutol therapy the decreased levels of Vit-E and Vit-B1 possibly play a role in the development of TON and may be used as therapeutic agents to lessen the deleterious effects of ethambutol.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rasul, Mahmud& Malik, Arif& Abd al-Mannan& Aziz, Khuram& Mahmud, Aminah& Kamal, Muhammad Amjad…[et al.]. 2015. Determination of potential role of antioxidative status and circulating biochemical markers in the pathogenesis of ethambutol induced toxic optic neuropathy among diabetic and non-diabetic patients. Saudi Journal of Biological Sciences،Vol. 22, no. 6, pp.739-743.
https://search.emarefa.net/detail/BIM-628558
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Malik, Arif…[et al.]. Determination of potential role of antioxidative status and circulating biochemical markers in the pathogenesis of ethambutol induced toxic optic neuropathy among diabetic and non-diabetic patients. Saudi Journal of Biological Sciences Vol. 22, no. 6 (Nov. 2015), pp.739-743.
https://search.emarefa.net/detail/BIM-628558
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rasul, Mahmud& Malik, Arif& Abd al-Mannan& Aziz, Khuram& Mahmud, Aminah& Kamal, Muhammad Amjad…[et al.]. Determination of potential role of antioxidative status and circulating biochemical markers in the pathogenesis of ethambutol induced toxic optic neuropathy among diabetic and non-diabetic patients. Saudi Journal of Biological Sciences. 2015. Vol. 22, no. 6, pp.739-743.
https://search.emarefa.net/detail/BIM-628558
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 743
رقم السجل
BIM-628558
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر